Plasma IL-36α and IL-36γ as Potential Biomarkers in Interstitial Lung Disease Associated with Rheumatoid Arthritis: a Pilot Study in the Chinese Population
Plasma IL-36α and IL-36γ as Potential Biomarkers in Interstitial Lung Disease Associated with Rheumatoid Arthritis: a Pilot Study in the Chinese Population
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血浆 IL-36α 和 IL-36γ 作为类风湿性关节炎相关间质性肺病的潜在生物标志物：中国人群的初步研究
DOI：
10.1007/s10753-022-01733-x
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发表时间：
2022-08
期刊：
影响因子：
5.1
通讯作者：
Zhenshun Cheng
中科院分区：
文献类型：
--
作者：
Weishuai Zheng;Xingxing Hu;Menglin Zou;Nie Hu;Weiwei Song;Rui Wang;Ying Liu;Qinhui Hou;Yuan Liu;Xiaoqi Chen;Zhenshun Cheng
间质性肺病（ILD）是类风湿关节炎（RA）的常见关节外表现，可增加RA患者的死亡率。ILD的早期识别，特别是预后不良的常见间质性肺炎（UIP）模式，对于指导RA-ILD的治疗和预防因诊断延迟而造成的损害非常重要。白细胞介素-36（IL-36）细胞因子参与结缔组织疾病。然而，IL-36在RA-ILD中的表达是未知的。在这项研究中，在中国人群中评估了39名RA-ILD患者和其他三组（30名健康对照、35名无ILD的RA患者和27名特发性肺纤维化[IPF]患者）血浆IL-36细胞因子的临床相关性。与HC和RA患者相比，RA-ILD患者血浆IL-36α和IL-36γ浓度升高。具有UIP模式的RA-ILD患者的血浆IL-36γ浓度高于不具有UIP模式的RA-ILD患者，但低于IPF患者。受试者工作曲线分析提示IL-36α和IL-36γ是RA患者ILD的潜在生物标志物。此外，IL-36γ用于区分具有UIP模式的RA-ILD与不具有UIP模式的RA-ILD的最佳临界值为555.40 pg/mL，用于区分RA-ILD与IPF的最佳临界值为655.10 pg/mL。RA-ILD患者血浆IL-36β或IL-36 Ra浓度与其他三组之间无显著差异。我们还发现，来自不同类型PF患者（包括RA-ILD和IPF）的肺以及来自博莱霉素诱导的PF小鼠的肺的特征是IL-36γ表达增加。我们的研究结果表明，使用IL-36细胞因子来识别RA患者进行进一步的ILD检查可能为目前临床可用的检测提供额外的诊断价值。此外，IL-36γ可能有助于确定RA-ILD患者中UIP模式的存在，并区分RA-ILD和IPF。
Interstitial lung disease (ILD) is a frequent extra-articular manifestation of rheumatoid arthritis (RA) and increases mortality in patients with RA. Early identification of ILD, especially the usual interstitial pneumonia (UIP) pattern with a poor prognosis, is important for guiding treatment of RA-ILD and preventing damage resulting from a delay in diagnosis. Interleukin-36 (IL-36) cytokines are involved in connective tissue diseases. However, IL-36 expression in RA-ILD is unknown. In this study, the clinical relevance of plasma IL-36 cytokines was evaluated in 39 patients with RA-ILD and three other groups (30 healthy controls 35 RA patients without ILD, and 27 patients with idiopathic pulmonary fibrosis [IPF) in the Chinese population. Plasma IL-36α and IL-36γ concentrations were elevated in patients with RA-ILD compared with those in HCs and patients with RA. RA-ILD patients with UIP pattern had higher plasma IL-36γ concentrations than those with RA-ILD without UIP, but these were lower than those in patients with IPF. Receiver operating curve analysis suggested that IL-36α and IL-36γ were potential biomarkers for identifying ILD in patients with RA. Additionally, the optimal cutoff value of IL-36γ for distinguishing RA-ILD with the UIP pattern from RA-ILD without UIP was 555.40 pg/mL and that for distinguishing RA-ILD from IPF was 655.10 pg/mL. No significant difference in plasma IL-36β or IL-36Ra concentrations was found between patients with RA-ILD and the three other groups. We also found that the lungs originating from different types of patients with PF, including RA-ILD and IPF, and those from mice following bleomycin-induced PF were characterized by increased IL-36γ expression. Our findings suggest that using IL-36 cytokines to identify patients with RA for further ILD workups may provide additional diagnostic value to the current clinically available assays. Moreover, IL-36γ may help to identify the presence of the UIP pattern in patients with RA-ILD and to discriminate RA-ILD from IPF.
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DOI：
10.1007/978-3-540-76735-0_8
发表时间：
2009
期刊：
Molecular and Cellular Neurosciences
影响因子：
--
作者：
P. Russell
通讯作者：
P. Russell
DOI：
--
发表时间：
2010
期刊：
--
影响因子：
--
作者：
D. Aletaha;T. Neogi;A. Silman;Julia Funovits;D. Felson;C. Bingham;N. Birnbaum;G. Burmester;V. Byker
通讯作者：
D. Aletaha;T. Neogi;A. Silman;Julia Funovits;D. Felson;C. Bingham;N. Birnbaum;G. Burmester;V. Byker
影响因子：
4.6
作者：
Boutet, M. -A.;Bart, G.;Blanchard, F.
通讯作者：
Blanchard, F.
类风湿性关节炎间质性肺疾病的发病率和死亡率：一项基于人群的研究。
影响因子：
--
作者：
Bongartz, Tim;Nannini, Carlotta;Medina-Velasquez, Yimy F.;Achenbach, Sara J.;Crowson, Cynthia S.;Ryu, Jay H.;Vassallo, Robert;Gabriel, Sherine E.;Matteson, Eric L.
通讯作者：
Matteson, Eric L.
影响因子：
5.6
作者：
Melton E;Qiu H
通讯作者：
Qiu H