Factors influencing scores on the social responsiveness scale.
Factors influencing scores on the social responsiveness scale.
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DOI：
10.1111/j.1469-7610.2012.02589.x
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发表时间：
2013-02
期刊：
影响因子：
--
通讯作者：
Lord C
中科院分区：
文献类型：
--
作者：
Hus V;Bishop S;Gotham K;Huerta M;Lord C
社会反应量表 (SRS) 是一种由家长填写的筛查问卷，通常用于衡量自闭症谱系障碍 (ASD) 的严重程度。尽管众所周知，儿童特征会影响其他 ASD 症状测量以及更广泛的家长问卷的分数，但对于非 ASD 特定因素如何影响 SRS 分数的解释的考虑有限。先前的研究探讨了行为问题对 SRS 特异性的影响，但尚未解决对使用 SRS 作为 ASD 症状定量测量的影响。对 2,368 名患有 ASD 的先证者和 1,913 名未受影响的兄弟姐妹进行了父母完成的 SRS 的原始评分 (SRS-Raw) 分析。回归分析用于评估 SRS 评分与人口、语言、认知和行为测量之间的关联。对于先证者来说，较高的 SRS-Raw 与更大的非 ASD 行为问题、更高的年龄、更受损的语言和认知技能以及其他家长报告的社会发展和 ASD 症状的得分相关。对于未受影响的兄弟姐妹，有更多的行为问题预示着更高的 SRS-Raw；男性、年龄较小以及较差的适应性社交和表达沟通能力也显示出虽小但显着的影响。当使用 SRS 作为定量表型测量时，必须考虑行为问题、年龄、表达语言或认知水平对分数的影响。如果不考虑非 ASD 特定因素的影响，则 SRS 评分更适合解释为指示一般损害程度，而不是 ASD 特定症状或社交损害的严重程度。需要进一步研究来考虑这些因素如何影响 SRS 在大型临床样本（包括患有 ASD 以外疾病的个体）中的敏感性和特异性。
The Social Responsiveness Scale (SRS) is a parent-completed screening questionnaire often used to measure ASD severity. Although child characteristics are known to influence scores from other ASD-symptom measures, as well as parent-questionnaires more broadly, there has been limited consideration of how non-ASD-specific factors may affect interpretation of SRS scores. Previous studies have explored effects of behavior problems on SRS specificity, but have not addressed influences on the use of the SRS as a quantitative measure of ASD-symptoms. Raw scores (SRS-Raw) from parent-completed SRS were analyzed for 2,368 probands with ASD and 1,913 unaffected siblings. Regression analyses were used to assess associations between SRS scores and demographic, language, cognitive, and behavior measures. For probands, higher SRS-Raw were associated with greater non-ASD behavior problems, higher age, and more impaired language and cognitive skills, as well as scores from other parent report measures of social development and ASD-symptoms. For unaffected siblings, having more behavior problems predicted higher SRS-Raw; male gender, younger age and poorer adaptive social and expressive communication skills also showed small, but significant effects. When using the SRS as a quantitative phenotype measure, the influence of behavior problems, age, and expressive language or cognitive level on scores must be considered. If effects of non-ASD-specific factors are not addressed, SRS scores are more appropriately interpreted as indicating general levels of impairment, than as severity of ASD-specific symptoms or social impairment. Further research is needed to consider how these factors influence the SRS’ sensitivity and specificity in large, clinical samples including individuals with disorders other than ASD.
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影响因子：
3.9
作者：
Gotham, Katherine;Pickles, Andrew;Lord, Catherine
通讯作者：
Lord, Catherine
DOI：
10.1176/appi.ajp.2010.09101470
发表时间：
2010-11
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Constantino JN;Zhang Y;Frazier T;Abbacchi AM;Law P
通讯作者：
Law P
DOI：
10.1097/01.chi.0000046811.95464.21
发表时间：
2003-04-01
影响因子：
13.3
作者：
Constantino, JN;Hudziak, JJ;Todd, RD
通讯作者：
Todd, RD
影响因子：
10.6
作者：
Constantino, JN;Todd, RD
通讯作者：
Todd, RD
DOI：
10.1111/j.1469-7610.2007.01762.x
发表时间：
2007-09-01
影响因子：
7.6
作者：
Corsello, Christina;Hus, Vanessa;Lord, Catherine
通讯作者：
Lord, Catherine