Case-control study of arsenic in drinking water and lung cancer in California and Nevada.
Case-control study of arsenic in drinking water and lung cancer in California and Nevada.
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DOI：
10.3390/ijerph10083310
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发表时间：
2013-08-02
影响因子：
--
通讯作者：
Steinmaus C
中科院分区：
文献类型：
--
作者：
Dauphiné DC;Smith AH;Yuan Y;Balmes JR;Bates MN;Steinmaus C
数百万人暴露于饮用水中的砷，高浓度的砷已知会导致人类肺癌。在较低浓度下，风险未知。我们在2002-2005年从内华达州西部和加州金斯县招募了196例肺癌病例和359例年龄和性别匹配的对照。校正年龄、性别、教育、吸烟和职业暴露后，砷浓度≥85 µg/L的比值比（中位数= 110 µg/L，平均值= 173 µg/L，最大值= 1，所有受试者中入组前40年以上的平均血药浓度（460 µg/L）为1.39（95% CI = 0.55-3.53），吸烟者中为1.61（95% CI = 0.59-4.38）。尽管比值比大于1.0，但考虑到入组前暴露超过40年的受试者数量较少，这些增加可能是偶然的。这项研究是在智利的研究表明砷相关癌症潜伏期为40年或更长时间之前设计的，说明了在美国等移动的人口低暴露国家确定砷相关健康影响所需的巨大样本量。
Millions of people are exposed to arsenic in drinking water, which at high concentrations is known to cause lung cancer in humans. At lower concentrations, the risks are unknown. We enrolled 196 lung cancer cases and 359 controls matched on age and gender from western Nevada and Kings County, California in 2002–2005. After adjusting for age, sex, education, smoking and occupational exposures, odds ratios for arsenic concentrations ≥85 µg/L (median = 110 µg/L, mean = 173 µg/L, maximum = 1,460 µg/L) more than 40 years before enrollment were 1.39 (95% CI = 0.55–3.53) in all subjects and 1.61 (95% CI = 0.59–4.38) in smokers. Although odds ratios were greater than 1.0, these increases may have been due to chance given the small number of subjects exposed more than 40 years before enrollment. This study, designed before research in Chile suggested arsenic-related cancer latencies of 40 years or more, illustrates the enormous sample sizes needed to identify arsenic-related health effects in low-exposure countries with mobile populations like the U.S. Nonetheless, our findings suggest that concentrations near 100 µg/L are not associated with markedly high relative risks.
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影响因子：
10.4
作者：
Smith AH;Marshall G;Yuan Y;Ferreccio C;Liaw J;von Ehrenstein O;Steinmaus C;Bates MN;Selvin S
通讯作者：
Selvin S
影响因子：
10.3
作者：
Marshall, Guillermo;Ferreccio, Catterina;Smith, Allan H.
通讯作者：
Smith, Allan H.
影响因子：
5
作者：
PICKLE, LW;BROWN, LM;BLOT, WJ
通讯作者：
BLOT, WJ
影响因子：
10.4
作者：
Gibb H;Haver C;Gaylor D;Ramasamy S;Lee JS;Lobdell D;Wade T;Chen C;White P;Sams R
通讯作者：
Sams R
影响因子：
10.4
作者：
SMITH, AH;HOPENHAYNRICH, C;SMITH, MT
通讯作者：
SMITH, MT