Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood.
Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood.
复制标题
DOI：
10.1289/ehp.8832
复制
发表时间：
2006-08
影响因子：
10.4
通讯作者：
Selvin S
中科院分区：
文献类型：
--
作者：
Smith AH;Marshall G;Yuan Y;Ferreccio C;Liaw J;von Ehrenstein O;Steinmaus C;Bates MN;Selvin S
饮用水中的砷是肺癌的既定原因，初步证据表明，摄入砷也可能导致非恶性肺部疾病。安托法加斯塔是智利第二大城市，从1958年开始，经历了一段非常高的砷暴露时期，一直持续到1971年，当时安装了一座砷去除厂。这种独特的暴露情景为研究早期砷暴露对死亡率的长期影响提供了难得的机会。在这项研究中，我们将1989年至2000年期间安托法加斯塔的死亡率与智利其他地区的死亡率进行了比较，重点是在接触高峰期间或之前出生的受试者，以及死亡时年龄在30-49岁之间的受试者。对于出生在高暴露时期之前(1950年至1957年)并在儿童早期暴露的出生队列，肺癌的标准化死亡率为7.0[95%可信区间5.48.9p<；0.001]，支气管扩张症的标化死亡率为12.4%(95%可信区间3.331.7p<；0.001)。对于出生在高暴露时期(1958年-1970年)且可能在宫内和儿童早期暴露的人，肺癌的SMR为6.1%(95%CI，3.5-9.9；P<；0.001)，支气管扩张的SMR为46.2%(95%CI，21.1-87.7；P<；0.001)。这些发现表明，在儿童早期或在宫内接触饮用水中的砷具有显著的肺部影响，极大地增加了年轻人随后死于恶性和非恶性肺部疾病的死亡率。
Arsenic in drinking water is an established cause of lung cancer, and preliminary evidence suggests that ingested arsenic may also cause nonmalignant lung disease. Antofagasta is the second largest city in Chile and had a distinct period of very high arsenic exposure that began in 1958 and lasted until 1971, when an arsenic removal plant was installed. This unique exposure scenario provides a rare opportunity to investigate the long-term mortality impact of early-life arsenic exposure. In this study, we compared mortality rates in Antofagasta in the period 1989–2000 with those of the rest of Chile, focusing on subjects who were born during or just before the peak exposure period and who were 30–49 years of age at the time of death. For the birth cohort born just before the high-exposure period (1950–1957) and exposed in early childhood, the standardized mortality ratio (SMR) for lung cancer was 7.0 [95% confidence interval (CI), 5.4–8.9; p < 0.001] and the SMR for bronchiectasis was 12.4 (95% CI, 3.3–31.7; p < 0.001). For those born during the high-exposure period (1958–1970) with probable exposure in utero and early childhood, the corresponding SMRs were 6.1 (95% CI, 3.5–9.9; p < 0.001) for lung cancer and 46.2 (95% CI, 21.1–87.7; p < 0.001) for bronchiectasis. These findings suggest that exposure to arsenic in drinking water during early childhood or in utero has pronounced pulmonary effects, greatly increasing subsequent mortality in young adults from both malignant and nonmalignant lung disease.
登录
查看更多内容
影响因子：
8.3
作者：
HANLON, DP;FERM, VH
通讯作者：
FERM, VH
影响因子：
10.4
作者：
Hopenhayn-Rich, C;Browning, SR;Gibb, H
通讯作者：
Gibb, H
影响因子：
5.4
作者：
Milton, AH;Smith, W;Ali, A
通讯作者：
Ali, A
影响因子：
5.4
作者：
Hopenhayn, C;Ferreccio, C;Hertz-Picciotto, I
通讯作者：
Hertz-Picciotto, I
DOI：
10.1080/09603120220129346
发表时间：
2002-06-01
影响因子：
3.2
作者：
Milton, AH;Rahman, M
通讯作者：
Rahman, M