Natural killer cells remember: an evolutionary bridge between innate and adaptive immunity?

Natural killer cells remember: an evolutionary bridge between innate and adaptive immunity?
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DOI:
10.1002/eji.200939435
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发表时间:
2009-08
影响因子:
5.4
通讯作者:
Lanier, Lewis L.
Lanier, Lewis L.
中科院分区:
医学3区
文献类型:
--
作者:
Sun, Joseph C.;Lanier, Lewis L.

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自三十年前发现以来,NK细胞一直被归类为先天免疫系统的细胞。研究表明,NK细胞对感染反应迅速且非特异性,被认为是维持早期先天免疫反应的功能桥梁,直到后来的获得性免疫反应得以启动。鉴于新的发现表明NK细胞几乎具有包括记忆在内的获得性免疫的所有特征,我们建议将NK细胞作为天然免疫和获得性免疫之间的“进化桥梁”。
Since their discovery three decades ago, NK cells have been classified as cells of the innate immune system. NK cells were shown to respond rapidly and non-specifically to infection, and were thought to act as a functional “bridge” to sustain the early innate immune response until the later adaptive immune responses could be mounted. In light of new findings showing how NK cells possess nearly all of the features of adaptive immunity including memory, we propose the placement of NK cells as an “evolutionary bridge” between innate and adaptive immunity.
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