Prevalence of respiratory viruses among adults, by season, age, respiratory tract region and type of medical unit in Paris, France, from 2011 to 2016.
Prevalence of respiratory viruses among adults, by season, age, respiratory tract region and type of medical unit in Paris, France, from 2011 to 2016.
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从2011年到2016年，成年人，季节，年龄，呼吸道区域以及法国巴黎的医疗单位类型的呼吸病毒患病率。
DOI：
10.1371/journal.pone.0180888
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Houhou-Fidouh N
中科院分区：
文献类型：
--
作者：
Visseaux B;Burdet C;Voiriot G;Lescure FX;Chougar T;Brugière O;Crestani B;Casalino E;Charpentier C;Descamps D;Timsit JF;Yazdanpanah Y;Houhou-Fidouh N
多重 PCR 检测通过广泛检测呼吸道病毒，提高了我们对呼吸道病毒流行病学的了解。我们在此描述了五年期间医院环境中这些病毒的负担。回顾性纳入2011年5月1日至2016年4月30日期间应医生要求通过多重PCR检测的成年患者（>20岁）的所有呼吸道样本。病毒检测结果按季节、患者年龄组、呼吸道区域（上呼吸道或下呼吸道）和临床病房类型（重症监护病房、肺科病房、肺移植病房和其他医疗病房）进行报告。总共纳入了 7196 个样本（4958 名患者）； 29.2% 的样本检测呈阳性，1.6% 的样本中检测到病毒双重感染。总体而言，两个病毒组占所有已识别病毒的 60.2%：小核糖核酸病毒（鼻病毒或肠道病毒，34.3%）和流感（26.6%）。流感病毒是冬季（34.4%）、上呼吸道（32%）和70岁以上患者（36.4%）中最常发现的病毒。小RNA病毒是这些人群和所有其他人群中第二常见的病毒组，包括下呼吸道感染（41.3%）或重症监护室患者（37.6%）。这项研究是欧洲迄今为止最大规模的研究，提供了病毒在医院环境中随季节、年龄组、临床单位类型和呼吸道区域分布的广泛情况。它强调了与被忽视的小核糖核酸病毒群相关的负担。这些数据对未来疫苗和抗病毒药物的开发具有重要意义。
Multiplex PCR tests have improved our understanding of respiratory viruses’ epidemiology by allowing their wide range detection. We describe here the burden of these viruses in hospital settings over a five-year period. All respiratory samples from adult patients (>20 years old) tested by multiplex-PCR at the request of physicians, from May 1 2011 to April 30 2016, were included retrospectively. Viral findings are reported by season, patient age group, respiratory tract region (upper or lower) and type of clinical unit (intensive care unit, pneumology unit, lung transplantation unit and other medical units). In total, 7196 samples (4958 patients) were included; 29.2% tested positive, with viral co-infections detected in 1.6% of samples. Overall, two viral groups accounted for 60.2% of all viruses identified: picornaviruses (rhinovirus or enterovirus, 34.3%) and influenza (26.6%). Influenza viruses constituted the group most frequently identified in winter (34.4%), in the upper respiratory tract (32%) and in patients over the age of 70 years (36.4%). Picornavirus was the second most frequently identified viral group in these populations and in all other groups, including lower respiratory tract infections (41.3%) or patients in intensive care units (37.6%). This study, the largest to date in Europe, provides a broad picture of the distribution of viruses over seasons, age groups, types of clinical unit and respiratory tract regions in the hospital setting. It highlights the burden associated with the neglected picornavirus group. These data have important implications for the future development of vaccines and antiviral drugs.
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影响因子：
5.1
作者：
Bennett, Nicholas J.;Tabarani, Christy M.;Domachowske, Joseph B.
通讯作者：
Domachowske, Joseph B.
影响因子：
4.9
作者：
Civardi, Elisa;Tzialla, Chryssoula;Stronati, Mauro
通讯作者：
Stronati, Mauro
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3.7
作者：
Hofstra, J. J.;Matamoros, S.;de Jong, M. D.
通讯作者：
de Jong, M. D.
影响因子：
9.4
作者：
Babady, N. Esther;Mead, Peter;Kamboj, Mini
通讯作者：
Kamboj, Mini
影响因子：
9.4
作者：
Kim, Hyun-Ki;Oh, Sung-Hee;Kim, Mi-Na
通讯作者：
Kim, Mi-Na