The effects of Staphylococcus aureus leukotoxins on the host: cell lysis and beyond.
The effects of Staphylococcus aureus leukotoxins on the host: cell lysis and beyond.
复制标题
DOI：
10.1016/j.mib.2013.01.012
复制
发表时间：
2013-02
影响因子：
5.4
通讯作者：
Torres VJ
中科院分区：
文献类型：
--
作者：
Yoong P;Torres VJ
The success of Staphylococcus aureus as a leading cause of deadly hospital-acquired and community-acquired infections is attributed to its high-level resistance to most antibiotics, and the multitude of virulence factors it elaborates. Most clinical isolates produce up to four bi-component pore-forming toxins capable of lysing cells of the immune system. Subtle differences in activity and target range of each leukotoxin suggest that these toxins are not redundant, but instead may have specialized functions in attacking and/or evading host defenses. In turn, the host has developed countermeasures recognizing sublytic levels of leukotoxins as signals to activate protective immune defenses. The opposing cytotoxic and immune-activating effects of leukotoxins on host cells make for a complex dynamic between S. aureus and the host.
登录
查看更多内容
影响因子：
3.6
作者：
Alonzo F 3rd;Benson MA;Chen J;Novick RP;Shopsin B;Torres VJ
通讯作者：
Torres VJ
影响因子：
6.4
作者：
Kobayashi, Scott D.;Malachowa, Natalia;DeLeo, Frank R.
通讯作者：
DeLeo, Frank R.
影响因子：
64.5
作者：
Gurcel, Laure;Abrami, Laurence;van der Goot, F. Gisou
通讯作者：
van der Goot, F. Gisou
影响因子：
3.5
作者：
KAMIO, Y;RAHMAN, A;IZAKI, K
通讯作者：
IZAKI, K
影响因子：
3.7
作者：
Diep, Binh An;Palazzolo-Ballance, Amy M.;Chambers, Henry F.
通讯作者：
Chambers, Henry F.