Tick vaccines and the control of tick-borne pathogens.
Tick vaccines and the control of tick-borne pathogens.
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DOI：
10.3389/fcimb.2013.00030
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发表时间：
2013
影响因子：
5.7
通讯作者：
de la Fuente J
中科院分区：
文献类型：
--
作者：
Merino O;Alberdi P;Pérez de la Lastra JM;de la Fuente J
蜱是专性食血性体外寄生虫，可将多种病原体传播给人类和动物。过去几年，世界范围内人类和家畜中蜱传疾病的发病率均有所增加，导致人们对蜱宿主与病原体相互作用的研究产生了更大的兴趣。载体和病原体基因组学以及蛋白质组学的进展推进了我们对节肢动物传播微生物定植和传播过程中发生的载体-病原体相互作用的了解。蜱传病原体通过差异基因表达从载体适应哺乳动物宿主，从而调节宿主过程。近年来研究表明，通过疫苗接种靶向蜱蛋白不仅可以减少蜱的摄食和繁殖，还能减少病原体从蜱到脊椎动物宿主的感染和传播。在本文中，我们回顾了已确定用于配制蜱疫苗的蜱保护性抗原以及这些疫苗对控制蜱传病原体的作用。
Ticks are obligate hematophagous ectoparasites that transmit a wide variety of pathogens to humans and animals. The incidence of tick-borne diseases has increased worldwide in both humans and domestic animals over the past years resulting in greater interest in the study of tick-host-pathogen interactions. Advances in vector and pathogen genomics and proteomics have moved forward our knowledge of the vector-pathogen interactions that take place during the colonization and transmission of arthropod-borne microbes. Tick-borne pathogens adapt from the vector to the mammalian host by differential gene expression thus modulating host processes. In recent years, studies have shown that targeting tick proteins by vaccination can not only reduce tick feeding and reproduction, but also the infection and transmission of pathogens from the tick to the vertebrate host. In this article, we review the tick-protective antigens that have been identified for the formulation of tick vaccines and the effect of these vaccines on the control of tick-borne pathogens.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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