Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic.
Immunological memory to common cold coronaviruses assessed longitudinally over a three-year period pre-COVID19 pandemic.
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DOI：
10.1016/j.chom.2022.07.012
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发表时间：
2022-09-14
影响因子：
30.3
通讯作者：
Sette, Alessandro
中科院分区：
文献类型：
--
作者：
Yu, Esther Dawen;Narowski, Tara M.;Wang, Eric;Garrigan, Emily;Mateus, Jose;Frazier, April;Weiskopf, Daniela;Grifoni, Alba;Premkumar, Lakshmanane;Antunes, Ricardo da Silva;Sette, Alessandro
对普通感冒冠状病毒（CCCs）的免疫记忆影响SARS-CoV-2的感染结局，了解其作用对于泛冠状病毒疫苗的开发至关重要。我们对2016 - 2019年年轻人的COVID 19大流行前样本进行了纵向分析，并评估了CCC特异性CD4 + T细胞和抗体应答。值得注意的是，CCC反应通常以与其他常见抗原相当的频率检测到，并随时间持续。CCC特异性CD4 + T细胞应答与低HLA-DR + CD38+信号相关，其幅度与每年CCC感染患病率无关。类似地，CCC特异性和加标RBD特异性IgG应答随时间稳定。最后，高CCC特异性CD4 + T细胞反应性，而不是抗体滴度，与预先存在的SARS-CoV-2免疫有关。这些结果为理解对地方性冠状病毒的免疫反应提供了有价值的参考，并表明稳定和持续的CCC反应可能来自稳定的记忆CD4 + T细胞库，这是由于重复的早期暴露和可能偶尔的再感染。yu等人对COVID大流行前的样本进行了一项纵向研究，发现普通感冒冠状病毒（CCC）的反应是持续的，并且随着时间的推移相对稳定。这种“稳定状态”可能是由于儿童时期的反复感染和偶尔的再次接触。这可能与SARS-CoV-2最终转变为地方病状态相似。
The immune memory to common cold coronaviruses (CCCs) influences SARS-CoV-2 infection outcome, and understanding its effect is crucial for pan-coronavirus vaccine development. We performed a longitudinal analysis of pre-COVID19-pandemic samples from 2016–2019 in young adults and assessed CCC-specific CD4+ T cell and antibody responses. Notably, CCC responses were commonly detected with comparable frequencies as with other common antigens and were sustained over time. CCC-specific CD4+ T cell responses were associated with low HLA-DR+CD38+ signals, and their magnitude did not correlate with yearly CCC infection prevalence. Similarly, CCC-specific and spike RBD-specific IgG responses were stable in time. Finally, high CCC-specific CD4+ T cell reactivity, but not antibody titers, was associated with pre-existing SARS-CoV-2 immunity. These results provide a valuable reference for understanding the immune response to endemic coronaviruses and suggest that steady and sustained CCC responses are likely from a stable pool of memory CD4+ T cells due to repeated earlier exposures and possibly occasional reinfections. Yu et al. conducted a longitudinal study on pre-COVID pandemic samples and found that common cold coronaviruses (CCCs) responses are sustained and relatively constant over time. This “steady state” might result from both repeated infections in childhood and occasional re-exposures. It potential parallels with SARS-CoV-2 eventual transition to an endemic state.
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影响因子：
16.6
作者：
Kundu R;Narean JS;Wang L;Fenn J;Pillay T;Fernandez ND;Conibear E;Koycheva A;Davies M;Tolosa-Wright M;Hakki S;Varro R;McDermott E;Hammett S;Cutajar J;Thwaites RS;Parker E;Rosadas C;McClure M;Tedder R;Taylor GP;Dunning J;Lalvani A
通讯作者：
Lalvani A
影响因子：
30.3
作者：
Lin CY;Wolf J;Brice DC;Sun Y;Locke M;Cherry S;Castellaw AH;Wehenkel M;Crawford JC;Zarnitsyna VI;Duque D;Allison KJ;Allen EK;Brown SA;Mandarano AH;Estepp JH;SJTRC Study Team;Taylor C;Molina-Paris C;Schultz-Cherry S;Tang L;Thomas PG;McGargill MA
通讯作者：
McGargill MA
影响因子：
15.9
作者：
Antunes, Ricardo da Silva;Babor, Mariana;Sette, Alessandro
通讯作者：
Sette, Alessandro
影响因子：
56.9
作者：
Kissler, Stephen M.;Tedijanto, Christine;Lipsitch, Marc
通讯作者：
Lipsitch, Marc
影响因子：
24.8
作者：
Kuri-Cervantes, Leticia;Pampena, Maria Betina;Betts, Michael R.
通讯作者：
Betts, Michael R.