A Novel Top-Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging-Guided Cancer Therapy.
A Novel Top-Down Synthesis of Ultrathin 2D Boron Nanosheets for Multimodal Imaging-Guided Cancer Therapy.
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用于多模态成像引导癌症治疗的超薄二维硼纳米片的新型自上而下合成
DOI：
10.1002/adma.201803031
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发表时间：
2018-07-18
期刊：
影响因子：
--
通讯作者：
Shi J
中科院分区：
文献类型：
--
作者：
Ji X;Kong N;Wang J;Li W;Xiao Y;Gan ST;Zhang Y;Li Y;Song X;Xiong Q;Shi S;Li Z;Tao W;Zhang H;Mei L;Shi J
单原子非金属二维纳米材料由于其独特的性质和生物相容性，在肿瘤纳米医学领域显示出巨大的潜力。本文采用热氧化刻蚀和液相剥离相结合的自顶向下的方法制备了厚度可控的硼纳米片（B NS）。基于聚乙二醇化的B NS，开发了一种新的光子药物递送平台，其表现出用于癌症治疗和成像的多个有希望的特征，包括（i）高效的NIR光到热转换，具有42.5%的高光热转换效率，（ii）高药物负载容量和由NIR光和中等酸性pH触发的药物释放，（iii）在肿瘤部位的强积累，（iv）多模式成像特性（光声、光热和荧光成像），和（v）完全的肿瘤消融和优异的生物相容性。据我们所知，这是第一个报告的自上而下的制造的二维B NS的组合热氧化蚀刻和液体剥离，以及他们的应用作为一个多模态成像引导药物输送平台。我们还希望新制备的B NS为各种生物医学应用提供一个强大的和有用的二维纳米平台。采用液相剥离和热氧化刻蚀相结合的自上而下的方法制备了超薄二维硼（B）基纳米片，并将其应用于肿瘤治疗和成像的光子药物传输。二维B NS平台具有高效的光热转换、高载药量、时空可控的药物释放、强的肿瘤蓄积、良好的生物相容性和多模式成像引导的癌症治疗的显著潜力等多种有前景的特征。
Single atom non-metal two-dimensional (2D) nanomaterials have shown considerable potential in cancer nanomedicines, owing to their intriguing properties and biocompatibility. Herein, ultrathin boron nanosheets (B NSs) were prepared through a novel top-down approach by coupling thermal oxidation etching and liquid exfoliation technologies, with controlled nanoscale thickness. Based on the PEGylated B NSs, a new photonic drug delivery platform was developed, which exhibited multiple promising features for cancer therapy and imaging, including (i) efficient NIR light to heat conversion with a high photothermal conversion efficiency of 42.5%, (ii) high drug-loading capacity and triggered drug release by NIR light and moderate acidic pH, (iii) strong accumulation at tumor sites, (iv) multimodal imaging properties (photoacoustic, photothermal and fluorescent imaging), and (v) complete tumor ablation and excellent biocompatibility. To the best of our knowledge, this is the first report on the top-down fabrication of ultrathin 2D B NSs by the combined thermal oxidation etching and liquid exfoliation, as well as their application as a multi-modal imaging-guided drug delivery platform. We also expect the newly prepared B NSs to provide a robust and useful 2D nanoplatform for various biomedical applications. Ultrathin 2D boron (B)-based nanosheets (NSs) were fabricated through a novel top-down approach by coupling liquid exfoliating and thermal oxidation etching, and applied to photonic drug delivery for cancer therapy and imaging. The 2D B NS platform exhibits multiple promising features including efficient photothermal conversion, high drug loading, spatiotemporally controlled drug release, strong tumor accumulation, good biocompatibility, and significant potential of multimodal imaging guided-cancer treatment.
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影响因子：
16.6
作者：
Chou, Stanley S.;Kaehr, Bryan;Kim, Jaemyung;Foley, Brian M.;De, Mrinmoy;Hopkins, Patrick E.;Huang, Jiaxing;Brinker, C. Jeffrey;Dravid, Vinayak P.
通讯作者：
Dravid, Vinayak P.
影响因子：
2.8
作者：
Nagarajan, V.;Chandiramouli, R.
通讯作者：
Chandiramouli, R.
影响因子：
29.4
作者：
Chen, Yu;Ye, Delai;Wang, Lianzhou
通讯作者：
Wang, Lianzhou
影响因子：
29.4
作者：
Lin, Han;Wang, Youwei;Shi, Jianlin
通讯作者：
Shi, Jianlin
影响因子：
15
作者：
Lin, Han;Gao, Shanshan;Shi, Jianlin
通讯作者：
Shi, Jianlin