Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis.
Comparison of patterns and prognosis among distant metastatic breast cancer patients by age groups: a SEER population-based analysis.
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按年龄组比较远处转移乳腺癌患者的模式和预后：基于 SEER 人群的分析
DOI：
10.1038/s41598-017-10166-8
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发表时间：
2017-08-23
影响因子：
4.6
通讯作者：
Jin W
中科院分区：
文献类型：
--
作者：
Chen MT;Sun HF;Zhao Y;Fu WY;Yang LP;Gao SP;Li LD;Jiang HL;Jin W
为了研究诊断年龄对转移性乳腺癌和患者预后的影响，我们从监测、流行病学和最终结果（SEER）数据库中收集了患者数据。我们最终确定了2010-2013年间诊断的4932例符合条件的转移性乳腺癌患者，包括850例年轻患者（<50岁），2，540例中年患者（50-69岁）和1，542例老年患者（>69岁）。结果显示，在IV期患者中，老年患者更容易发生肺转移（P < 0.001），而仅发生远处淋巴结转移的可能性较小（P = 0.004）。多部位转移的比例青年组（34.9%）和中年组（36.2%）明显高于老年组（28.3%）（P < 0.001）。在生存分析中，年轻患者的总生存期（χ2 = 121.9，P < 0.001）和乳腺癌特异性生存期（χ2 = 69.8，P < 0.001）均最好，而老年患者的预后最差。诊断时的年龄是转移性乳腺癌患者的独立预后因素。只有骨转移患者的生存率上级其他转移患者（P < 0.001）。单纯脑转移组和多部位转移组预后最差（P < 0.05）。我们希望这些结果将为更好地了解远处转移性乳腺癌提供见解。
To investigate the effects of age at diagnosis on metastatic breast cancer and patients’ prognosis, we collected patient data from the Surveillance, Epidemiology, and End Results (SEER) database. We finally identified 4932 eligible metastatic breast cancer patients diagnosed between 2010–2013, including 850 younger patients (<50 years), 2,540 middle-aged patients (50–69 years) and 1,542 elder patients (>69 years). The results revealed that in stage IV patients, elder patients were more likely to have lung metastasis (P < 0.001) and less likely to have only distant lymphatic spread (P = 0.004). Higher proportion of younger (34.9%) and middle-aged (36.2%) patients had multiple metastatic sites than elder patients (28.3%) (P < 0.001). In survival analysis, younger patients presented the best prognosis, while elder patients had the worst both in overall survival (χ2 = 121.9, P < 0.001) and breast cancer-specific survival (χ2 = 69.8, P < 0.001). Age at diagnosis was an independent prognostic factor for metastatic breast cancer patients. Moreover, patients with bone metastasis only had superior survival compared to other metastatic patients (P < 0.001). Brain metastasis only group and multiple sites metastasis group had the poorest prognosis (P < 0.05). We hope the results will provide insights into a better understanding of distant metastatic breast cancer.
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影响因子：
3.9
作者：
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通讯作者：
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影响因子：
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