The association between ambient air pollutants and pancreatic cancer in the Multiethnic Cohort Study.
The association between ambient air pollutants and pancreatic cancer in the Multiethnic Cohort Study.
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DOI：
10.1016/j.envres.2021.111608
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发表时间：
2021-11
影响因子：
8.3
通讯作者：
Setiawan VW
中科院分区：
文献类型：
--
作者：
Bogumil D;Wu AH;Stram D;Yang J;Tseng CC;Le Marchand L;Wu J;Cheng I;Setiawan VW
以前研究环境空气污染物与胰腺癌之间的关系的研究是在种族/人种相同的样本中进行的，结果喜忧参半，一些研究支持与细颗粒物有关的证据。为了进一步调查这些发现，我们使用克里格插值法对来自多种族队列研究的100527名男性和女性的颗粒物(PM2.5、PM10)和氮氧化物(NOX和NO2)的暴露水平进行了估计，这些人从1993年到2013年主要居住在洛杉矶县。我们使用COX比例风险模型测量了这些空气污染物与胰腺癌发病的相关性，该模型采用时变污染物测量方法，并对混杂因素进行了调整。在研究期间，共有821例胰腺癌和1,660,488人年累积，平均随访时间超过16年。PM2.5(每10μg/m~3)与胰腺癌相关(危险比[HR]=1.6 1；95%CI：1.0 9，2.37)。这种与PM2.5的关联在拉丁裔(HR=3.59；95%CI，1.60，8.06)和曾经吸烟者(HR=1.76；95%CI，1.05，2.94)中最强。与PM10(HR=1.12；95%CI，0.94，1.32，每10μg/m~3)、NOx(HR=1.14；95%CI，0.88，1.48，每50 ppb)或NO2(HR=1.14；95%CI，0.85，1.54，每20 ppb)无关。我们的发现支持了先前的研究，确定了细颗粒物、PM2.5和胰腺癌之间的联系。尽管在统计上不是异质性的，但这种联系在拉丁裔和吸烟者中最为明显。未来的研究需要在城市环境和种族/族裔多样化的人口中复制这些结果。
Prior studies examining the association between ambient air pollutants and pancreatic cancer have been conducted in racially/ethnically homogeneous samples and have produced mixed results, with some studies supporting evidence of an association with fine particulate matter. To further investigate these findings, we estimated exposure levels of particulate matter (PM2.5, PM10,) and oxides of nitrogen (NOX, and NO2) using kriging interpolation for 100,527 men and women from the Multiethnic Cohort Study, residing largely in Los Angeles County from 1993 through 2013. We measured the association between these air pollutants and incident pancreatic cancer using Cox proportional hazards models with time-varying pollutant measures, with adjustment for confounding factors. A total of 821 incident pancreatic cancer and 1,660,488 person-years accumulated over the study period, with an average follow-up time of over 16 years. PM2.5 (per 10 μg/m3) was associated with incident pancreatic cancer (hazard ratio [HR] = 1.61; 95% CI, 1.09, 2.37). This PM2.5 -association was strongest among Latinos (HR = 3.59; 95% CI, 1.60, 8.06) and ever smokers (HR = 1.76; 95% CI, 1.05, 2.94). There was no association for PM10 (HR = 1.12; 95% CI, 0.94, 1.32, per 10 μg/m3), NOX (HR = 1.14; 95% CI, 0.88, 1.48, per 50 ppb), or NO2 (HR = 1.14; 95% CI, 0.85, 1.54, per 20 ppb). Our findings support prior research identifying an association between fine particulate matter, PM2.5, and pancreatic cancer. Although not statistically heterogeneous, this association was most notable among Latinos and smokers. Future studies are needed to replicate these results in an urban setting and in a racially/ethnically diverse population.
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