Modifying pathways by age and sex for the association between combined sleep disordered breathing and long sleep duration with neurocognitive decline in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Modifying pathways by age and sex for the association between combined sleep disordered breathing and long sleep duration with neurocognitive decline in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
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DOI：
10.1002/alz.12361
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Ramos AR
中科院分区：
文献类型：
--
作者：
Kaur SS;Tarraf W;Wu B;Gonzalez KA;Daviglus M;Shah N;Sotres-Alvarez D;Gallo LC;Wohlgemuth W;Redline S;Gonzalez HM;Ramos AR
确定肥胖或代谢综合征（MetS）是否改变了不同年龄和性别组的美国西班牙裔/拉丁裔（N= 5，500）社区队列中睡眠呼吸障碍（SDB）、自我报告的睡眠持续时间（SD）和SDB/SD合并7年神经认知下降（ND）表型之间的相关性。暴露量为基线SDB（REI ≥ 15）、嗜睡（ESS ≥ 10）、SD（<6小时、6-9小时、≥ 9小时）。结果是7年ND。平均年龄为56.0岁，54.8%为女性。肥胖改变了最大年龄组中SDB/SD和ND在记忆（F=21.49，p<0.001）、整体认知（F=9.14，p<0.001）方面的关联。无代谢综合征合并长时间睡眠/SDB的女性在整体认知方面表现出最明显的下降（F=3.07，p=0.010）。SDB/长时间睡眠与记忆力和整体认知能力下降之间的关联在肥胖的老年人中最为明显。在女性中，MetS状态改变了长时间睡眠/SDB与整体认知下降之间的关联。
To determine if obesity or metabolic syndrome (MetS) modifies associations between sleep-disordered breathing (SDB), self-reported sleep duration (SD) and phenotypes of combined SDB/SD with 7-year neurocognitive decline (ND) in a community based-cohort of U.S. Hispanic/Latinos (N=5,500) in different age and sex groups. The exposures were baseline SDB (REI ≥ 15), sleepiness (ESS ≥ 10), SD (<6 hours, 6–9 hours, ≥ 9 hours). The outcome was 7-year ND. Mean age was 56.0 years, 54.8% females. Obesity modified the association between SDB/SD and ND in memory (F=21.49, p<0.001), global cognition (F=9.14, p<0.001) in the oldest age group. Women without MetS with combined long sleep/SDB exhibited most pronounced decline in global cognition (F=3.07, p=0.010). The association between combined SDB/long sleep and declines in memory and global cognition was most pronounced in obese older adults. Among women, MetS status modified the association between long sleep/SDB and decline in global cognition.
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影响因子：
5.6
作者：
Lavange, Lisa M.;Kalsbeek, William D.;Sorlie, Paul D.;Aviles-Santa, Larissa M.;Kaplan, Robert C.;Barnhart, Janice;Liu, Kiang;Giachello, Aida;Lee, David J.;Ryan, John;Criqui, Michael H.;Elder, John P.
通讯作者：
Elder, John P.
影响因子：
3.1
作者：
Haimov, Iris;Hanuka, Einat;Horowitz, Yael
通讯作者：
Horowitz, Yael
影响因子：
2.6
作者：
Foret, Janelle T.;Oleson, Stephanie;Haley, Andreana P.
通讯作者：
Haley, Andreana P.
影响因子：
4.5
作者：
Cespedes EM;Dudley KA;Sotres-Alvarez D;Zee PC;Daviglus ML;Shah NA;Talavera GA;Gallo LC;Mattei J;Qi Q;Ramos AR;Schneiderman N;Espinoza-Giacinto RA;Patel SR
通讯作者：
Patel SR
影响因子：
14
作者：
Gonzalez, Hector M.;Tarraf, Wassim;Schneiderman, Neil
通讯作者：
Schneiderman, Neil