Association of adiponectin with type 2 diabetes and hypertension in African American men and women: the Jackson Heart Study.
Association of adiponectin with type 2 diabetes and hypertension in African American men and women: the Jackson Heart Study.
复制标题
非裔美国人男女的脂联素与2型糖尿病和高血压的关联：杰克逊心脏研究。
DOI：
10.1186/s12872-015-0005-5
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发表时间：
2015-02-25
影响因子：
2.1
通讯作者：
Bidulescu A
中科院分区：
文献类型：
--
作者：
Davis SK;Gebreab SY;Xu R;Riestra P;Khan RJ;Sumner AE;Hickson D;Bidulescu A
脂联素是与2型糖尿病和高血压相关的生物标志物。低循环水平是一个危险因素。更高的水平是保护性的。与其他种族/民族相比，非裔美国人2型糖尿病和高血压的患病率较高，脂联素水平较低。关于脂联素与非裔美国人这些健康结果之间的关联知之甚少。这项研究的目的是评估脂联素与杰克逊心脏研究中非裔美国男性和女性2型糖尿病和高血压可能性的相关性。以2型糖尿病和高血压为结局的横断面数据为基础，按性别分层进行单独的多变量logistic回归分析。将脂联素分为四个四分位数，以最高四分位数作为参考。从2000年至2004年收集了3 663名参与者的数据。数据分析于2014日历年进行。双尾P < .05被确定为显著性水平。在校正的多变量模型中，脂联素水平与女性2型糖尿病呈负相关（比值比[OR]，95%置信区间[CI] = 1.47，[1.02，2.11]，P = 0.04）。男人之间没有联系。脂联素水平最低的女性患高血压的可能性较小（OR，95% CI = 0.66，[0.46，0.95]，p = 0.02）。男人之间没有联系。研究结果揭示了非裔美国妇女脂联素水平与2型糖尿病和高血压可能性之间的差异性关联。需要更多的研究来阐明这种差异关联。
Adiponectin is a biomarker that is associated with type 2 diabetes and hypertension. Lower circulating level is a risk factor. Higher levels are protective. African Americans have a higher prevalence of type 2 diabetes and hypertension and lower levels of adiponectin when compared to other racial/ethnic groups. Little is known about the association of adiponectin on these health outcomes among African Americans. The purpose of the study was to assess the association of adiponectin on type 2 diabetes and hypertension likelihood among African American men and women in the Jackson Heart Study. Separate multivariate logistic regressions were conducted stratified by sex based on cross-sectional data with type 2 diabetes and hypertension as the outcomes. Adiponectin was divided into four quartiles with the highest quartile as the reference. Data was collected from 2000-2004 on 3,663 participants. Data analysis was conducted in calendar year 2014. Two- tailed P < .05 was established as level of significance. In the adjusted multivariate models, adiponectin level was inversely associated with type 2 diabetes among women (odds ratio [OR], 95% confidence interval [CI] = 1.47, [1.02, 2.11], P = .04). There was no association among men. Women with the lowest level of adiponectin were less likely to be hypertensive (OR, 95% CI = 0.66, [0.46, 0.95], p = .02). There was no association among men. Findings reveal differential associations between levels of adiponectin with type 2 diabetes and hypertension likelihood among African American women. More research is needed to elucidate this differential association.
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