Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction.
Aerobic Interval Training Regulated SIRT3 Attenuates High-Fat-Diet-Associated Cognitive Dysfunction.
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有氧间歇训练调节 SIRT3 可减轻高脂肪饮食相关的认知功能障碍
DOI：
10.1155/2018/2708491
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发表时间：
2018
影响因子：
--
通讯作者：
Ma H
中科院分区：
文献类型：
--
作者：
Shi Z;Li C;Yin Y;Yang Z;Xue H;Mu N;Wang Y;Liu M;Ma H
Cognitive dysfunction is an important complicated disease in obesity. Exercise ameliorates obesity and the related cognitive dysfunction. However, the underlying mechanism is still unclear. In this study, we investigated whether aerobic interval training (AIT) could attenuate high-fat-diet- (HFD-) associated cognitive dysfunction and the possible mechanism of SIRT3-MnSOD pathway. C57BL/6 wild-type (WT) mice and SIRT3 knockout (KO) mice were randomized into control (Con) or HFD group with or without AIT training for 6 weeks. The spatial learning and memory ability were impaired in HFD group compared to the control group. The levels of mitochondrial protein acetylation were increased in the hippocampus of HFD group. The acetylation level of antioxidative MnSOD was increased as well. As a result, the ROS and MDA levels were significantly increased, which leads to the neuron apoptosis in the hippocampus. SIRT3 deficiency further aggravated HFD-induced cognitive dysfunction and susceptibility to oxidative stress injury. However, AIT upregulated neuron SIRT3 expression and decreased the acetylation of MnSOD. The hippocampus neuron oxidative stress and apoptosis were both decreased compared to untrained HFD group, which finally improved cognitive function of HFD mice. Collectively, AIT attenuates HFD-associated cognitive dysfunction through SIRT3 upregulation and improvement of antioxidative MnSOD activity.
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影响因子：
16
作者：
Hirschey MD;Shimazu T;Jing E;Grueter CA;Collins AM;Aouizerat B;Stančáková A;Goetzman E;Lam MM;Schwer B;Stevens RD;Muehlbauer MJ;Kakar S;Bass NM;Kuusisto J;Laakso M;Alt FW;Newgard CB;Farese RV Jr;Kahn CR;Verdin E
通讯作者：
Verdin E
SIRT3 线粒体脱乙酰酶在细胞生理学、癌症和神经退行性疾病中的功能。
影响因子：
7.8
作者：
Ansari A;Rahman MS;Saha SK;Saikot FK;Deep A;Kim KH
通讯作者：
Kim KH
影响因子：
3.6
作者：
通讯作者：
--
影响因子：
5.6
作者：
Kemi, Ole Johan;Ceci, Marcello;Ellingsen, Oyvind
通讯作者：
Ellingsen, Oyvind
影响因子：
25
作者：
van Praag, H;Kempermann, G;Gage, FH
通讯作者：
Gage, FH