Abnormal task driven neural oscillations in multiple sclerosis: A visuomotor MEG study.
Abnormal task driven neural oscillations in multiple sclerosis: A visuomotor MEG study.
复制标题
DOI：
10.1002/hbm.23531
复制
发表时间：
2017-05
影响因子：
4.8
通讯作者：
Brookes MJ
中科院分区：
文献类型：
--
作者：
Barratt EL;Tewarie PK;Clarke MA;Hall EL;Gowland PA;Morris PG;Francis ST;Evangelou N;Brookes MJ
多发性硬化症(MS)是一种衰弱的疾病，通常归因于白质髓鞘的退化。症状包括疲劳，以及与视力和运动有关的问题。虽然在接受核磁共振扫描的患者中经常观察到白质脱髓鞘的区域，但这种测量通常不能很好地预测疾病的严重程度。因此，测量大脑功能的相关变化是有指导意义的。广泛的白质脱髓鞘可能导致神经元活动传播的延迟，由于其良好的时间分辨率，脑磁图可以在受控条件下(例如，在任务期间)探测这种延迟。在健康受试者中，对视觉运动任务的反应是有据可查的：在运动皮质，运动引起β波段振荡功率的局部下降(事件相关的β振荡去同步)，随后运动停止时高于基线水平(运动后β反弹(PMBR))。在视觉皮质中，视觉刺激会产生更多的伽马振荡。在这项研究中，我们使用视觉运动范式来测量MS患者的这些反应，并将他们与年龄和性别匹配的健康对照组进行比较。我们发现患者的PMBR达到峰值的时间显着增加，这与符号数字模式测试显着相关：符号数字模式测试是信息处理速度的衡量标准。患者的视觉伽马振荡的幅度也显著降低。这些发现突出了电生理成像在对MS患者的视觉障碍和异常运动控制产生新的理解方面的潜在价值。Hum Brain Mapp 38：2441-2453,2017。©2017威利期刊公司。
Multiple sclerosis (MS) is a debilitating disease commonly attributed to degradation of white matter myelin. Symptoms include fatigue, as well as problems associated with vision and movement. Although areas of demyelination in white matter are observed routinely in patients undergoing MRI scans, such measures are often a poor predictor of disease severity. For this reason, it is instructive to measure associated changes in brain function. Widespread white‐matter demyelination may lead to delays of propagation of neuronal activity, and with its excellent temporal resolution, magnetoencephalography can be used to probe such delays in controlled conditions (e.g., during a task). In healthy subjects, responses to visuomotor tasks are well documented: in motor cortex, movement elicits a localised decrease in the power of beta band oscillations (event‐related beta desynchronisation) followed by an increase above baseline on movement cessation (post‐movement beta rebound (PMBR)). In visual cortex, visual stimulation generates increased gamma oscillations. In this study, we use a visuomotor paradigm to measure these responses in MS patients and compare them to age‐ and gender‐matched healthy controls. We show a significant increase in the time‐to‐peak of the PMBR in patients which correlates significantly with the symbol digit modalities test: a measure of information processing speed. A significant decrease in the amplitude of visual gamma oscillations in patients is also seen. These findings highlight the potential value of electrophysiological imaging in generating a new understanding of visual disturbances and abnormal motor control in MS patients. Hum Brain Mapp 38:2441–2453, 2017. © 2017 Wiley Periodicals, Inc.
登录
查看更多内容
影响因子：
13.9
作者：
Buzsáki G;Wang XJ
通讯作者：
Wang XJ
DOI：
10.1073/pnas.1517629112
发表时间：
2015-11-03
影响因子：
11.1
作者：
Feingold, Joseph;Gibson, Daniel J.;Graybiel, Ann M.
通讯作者：
Graybiel, Ann M.
影响因子：
3.7
作者：
Friedman-Hill, S;Maldonado, PE;Gray, CM
通讯作者：
Gray, CM
影响因子：
3.6
作者：
Benedict, RHB;Schretlen, D;Shpritz, B
通讯作者：
Shpritz, B
影响因子：
4.7
作者：
Alegre, M.;Alvarez-Gerriko, I.;Artieda, J.
通讯作者：
Artieda, J.