A soft and stretchable bilayer electrode array with independent functional layers for the next generation of brain machine interfaces.
A soft and stretchable bilayer electrode array with independent functional layers for the next generation of brain machine interfaces.
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一种柔软且可伸展的双层电极阵列，具有独立的功能层，用于下一代脑机接口。
DOI：
10.1088/1741-2552/abb4a5
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发表时间：
2020-10-14
影响因子：
4
通讯作者：
Greger B
中科院分区：
文献类型：
--
作者：
Graudejus O;Barton C;Ponce Wong RD;Rowan CC;Oswalt D;Greger B
脑机接口（BMI）对于推进神经修复术、机器人技术以及为严重神经系统疾病提供治疗选择有着巨大的前景。这项工作的目标是开发和体内评估 BMI 电极，以满足在大面积皮层上以亚毫米分辨率记录大脑活动的需求，同时具有柔软性和机电鲁棒性（即可拉伸）。当前的电极需要在高时空分辨率和皮质覆盖面积之间进行权衡。为了满足同时高分辨率和大皮质覆盖的需求，本研究中开发的原型电极阵列采用了一种新颖的双层布线，将柔软且可拉伸的引线从大脑表面的记录位点（皮质电图，ECoG）连接到数据采集系统。为了验证记录特性，该阵列被植入健康猫科动物体内长达五个月。从该装置的两层记录的神经信号显示出局部场电位（LFP）信号典型的升高的中频结构，该信号在植入期间振幅稳定，并且在 Telazol 麻醉诱导后也表现出一致的频率依赖性调制。柔软、可拉伸的大面积、高分辨率微ECoG电极阵列（lahrμECoG）的成功开发是满足先进BMI应用的神经技术需求的重要一步。
Brain-Machine Interfaces (BMIs) hold great promises for advancing neuroprosthetics, robotics, and for providing treatment options for severe neurological diseases. The objective of this work is the development and in vivo evaluation of electrodes for BMIs that meet the needs to record brain activity at sub-millimeter resolution over a large area of the cortex while being soft and electromechanically robust (i.e., stretchable). Current electrodes require a trade-off between high spatiotemporal resolution and cortical coverage area. To address the needs for simultaneous high resolution and large cortical coverage, the prototype electrode array developed in this study employs a novel bilayer routing of soft and stretchable lead wires from the recording sites on the surface of the brain (electrocorticography, ECoG) to the data acquisition system. To validate the recording characteristics, the array was implanted in healthy felines for up to five months. Neural signals recorded from both layers of the device showed elevated mid-frequency structures typical of local field potential (LFP) signals that were stable in amplitude over implant duration, and also exhibited consistent frequency-dependent modulation after anesthesia induction by Telazol. The successful development of a soft and stretchable large-area, high resolution micro ECoG electrode array (lahrμECoG) is an important step to meet the neurotechnological needs of advanced BMI applications.
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影响因子：
19
作者：
Ganji, Mehran;Kaestner, Erik;Dayeh, Shadi A.
通讯作者：
Dayeh, Shadi A.
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
4.7
作者：
Kellis, Spencer;Sorensen, Larry;Greger, Bradley
通讯作者：
Greger, Bradley
影响因子：
4
作者：
Degenhart AD;Eles J;Dum R;Mischel JL;Smalianchuk I;Endler B;Ashmore RC;Tyler-Kabara EC;Hatsopoulos NG;Wang W;Batista AP;Cui XT
通讯作者：
Cui XT
影响因子：
4
作者：
Kellis S;Miller K;Thomson K;Brown R;House P;Greger B
通讯作者：
Greger B