Substrates of neuropsychological functioning in stimulant dependence: a review of functional neuroimaging research.
Substrates of neuropsychological functioning in stimulant dependence: a review of functional neuroimaging research.
复制标题
DOI：
10.1002/brb3.65
复制
发表时间：
2012-07
影响因子：
3.1
通讯作者：
van den Brink, Wim
中科院分区：
文献类型：
--
作者：
Crunelle, Cleo L.;Veltman, Dick J.;Booij, Jan;van Emmerik-van Oortmerssen, Katelijne;van den Brink, Wim
兴奋剂依赖与神经心理障碍有关。在这里，我们总结并整合了现有的关于兴奋剂依赖中神经心理（障碍）功能的神经基础的神经影像学文献，包括可卡因、（甲基）安非他明、摇头丸和尼古丁依赖以及咖啡因的过量使用，将兴奋剂滥用者（SA）与使用健康对照（HC）的非药物进行比较。尽管存在一些不一致之处，但大多数研究表明，与 HC 相比，SA 中的前额叶皮层 (PFC) 和岛叶响应奖励和惩罚的大脑激活发生了改变，并且在渴望和注意偏差范式期间，边缘叶和前扣带皮层 (ACC)/PFC 的激活有所改变。与 HC 相比，SA 的冲动性与较低的 ACC 和前补充运动区活动相关，并且与腹侧（杏仁核、腹外侧 PFC、岛叶）和背侧（背外侧 PFC、背侧 ACC、后顶叶皮层）系统相关。 SA 中的决策与低背外侧 PFC 活动和高眶额活动相关。最后，与 HC 相比，SA 的执行功能与额颞叶区的较低激活和前运动皮层的较高激活相关。结论是，与 HC 相比，较低的激活可能反映了神经认知功能受损的神经基质，而与 HC 相比，SA 的较高激活可能反映了补偿性认知控制机制，以将行为任务表现保持在与 HC 相似的水平。然而，在得出最终结论之前，需要在 SA 和 HC 中使用神经影像学进行更多研究，使用更大、更同质的样本以及更具可比性的任务范式、研究设计和统计分析。
Stimulant dependence is associated with neuropsychological impairments. Here, we summarize and integrate the existing neuroimaging literature on the neural substrates of neuropsychological (dys)function in stimulant dependence, including cocaine, (meth-)amphetamine, ecstasy and nicotine dependence, and excessive caffeine use, comparing stimulant abusers (SAs) to nondrug using healthy controls (HCs). Despite some inconsistencies, most studies indicated altered brain activation in prefrontal cortex (PFC) and insula in response to reward and punishment, and higher limbic and anterior cingulate cortex (ACC)/PFC activation during craving and attentional bias paradigms in SAs compared with HCs. Impulsivity in SAs was associated with lower ACC and presupplementary motor area activity compared with HCs, and related to both ventral (amygdala, ventrolateral PFC, insula) and dorsal (dorsolateral PFC, dorsal ACC, posterior parietal cortex) systems. Decision making in SAs was associated with low dorsolateral PFC activity and high orbitofrontal activity. Finally, executive function in SAs was associated with lower activation in frontotemporal regions and higher activation in premotor cortex compared with HCs. It is concluded that the lower activations compared with HCs are likely to reflect the neural substrate of impaired neurocognitive functions, whereas higher activations in SAs compared with HCs are likely to reflect compensatory cognitive control mechanisms to keep behavioral task performance to a similar level as in HCs. However, before final conclusions can be drawn, additional research is needed using neuroimaging in SAs and HCs using larger and more homogeneous samples as well as more comparable task paradigms, study designs, and statistical analyses.
登录
查看更多内容
影响因子：
3.6
作者：
Crews, Fulton Timm;Boettiger, Charlotte Ann
通讯作者：
Boettiger, Charlotte Ann
影响因子：
2.9
作者：
Bustamante, Juan-Carlos;Barros-Loscertales, Alfonso;Avila, Cesar
通讯作者：
Avila, Cesar
影响因子：
5.7
作者：
Bolla, KI;Eldreth, DA;Ernst, M
通讯作者：
Ernst, M
影响因子：
--
作者：
Adinoff, Bryon;Williams, Mark J;Devous, Michael D Sr
通讯作者：
Devous, Michael D Sr
影响因子：
5.2
作者：
Chen BT;Hopf FW;Bonci A
通讯作者：
Bonci A