Pulmonary impairment after tuberculosis and its contribution to TB burden.
Pulmonary impairment after tuberculosis and its contribution to TB burden.
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DOI：
10.1186/1471-2458-10-259
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发表时间：
2010-05-19
影响因子：
4.5
通讯作者：
Weis SE
中科院分区：
文献类型：
--
作者：
Pasipanodya JG;McNabb SJ;Hilsenrath P;Bae S;Lykens K;Vecino E;Munguia G;Miller TL;Drewyer G;Weis SE
结核病治疗后肺功能损害对健康的影响尚未纳入结核病负担评估。因此，以前的全球和国家结核病负担估计数没有反映结核病幸存的全部后果。我们评估了结核病的负担，包括肺结核后肺功能损害在塔兰特县，得克萨斯州使用残疾调整生命年（DIMs）。使用与全球疾病负担研究相同的方法和生命表，计算了2005年1月至2006年12月期间在塔兰特县公共卫生中心接受治疗的所有经培养确诊的结核病患者的结核病负担。寿命损失年数是根据标准化寿命表的预期寿命与结核病死亡年龄之间的差异计算的。残疾生存年数是根据年龄和性别特异性结核病发病率，使用已公布的残疾权重计算的。结核病的非致命性健康影响被分为急性残疾生活年和慢性残疾生活年。急性残疾生存年定义为在完成治疗前因疾病造成的结核病负担，包括治疗相关副作用造成的负担。慢性残疾生活年数被定义为结核病后肺功能损害导致的残疾造成的结核病负担。在此期间有224例结核病病例，其中177例经培养确诊。这177例受试者共丢失了1189个DADs。在这1189个残疾人中，23%来自寿命损失年，2%来自急性残疾年，75%来自慢性残疾年。我们的研究结果表明，结核病的疾病负担比以前估计的要大。肺结核后的肺损伤是造成大部分负担的原因。这些数据表明，成功的结核病控制工作可能比以前认识到的更能减轻健康负担。
The health impacts of pulmonary impairment after tuberculosis (TB) treatment have not been included in assessments of TB burden. Therefore, previous global and national TB burden estimates do not reflect the full consequences of surviving TB. We assessed the burden of TB including pulmonary impairment after tuberculosis in Tarrant County, Texas using Disability-adjusted Life Years (DALYs). TB burden was calculated for all culture-confirmed TB patients treated at Tarrant County Public Health between January 2005 and December 2006 using identical methods and life tables as the Global Burden of Disease Study. Years of life-lost were calculated as the difference between life expectancy using standardized life tables and age-at-death from TB. Years lived-with-disability were calculated from age and gender-specific TB disease incidence using published disability weights. Non-fatal health impacts of TB were divided into years lived-with-disability-acute and years lived-with-disability-chronic. Years lived-with-disability-acute was defined as TB burden resulting from illness prior to completion of treatment including the burden from treatment-related side effects. Years lived-with-disability-chronic was defined as TB burden from disability resulting from pulmonary impairment after tuberculosis. There were 224 TB cases in the time period, of these 177 were culture confirmed. These 177 subjects lost a total of 1189 DALYs. Of these 1189 DALYs 23% were from years of life-lost, 2% were from years lived-with-disability-acute and 75% were from years lived-with-disability-chronic. Our findings demonstrate that the disease burden from TB is greater than previously estimated. Pulmonary impairment after tuberculosis was responsible for the majority of the burden. These data demonstrate that successful TB control efforts may reduce the health burden more than previously recognized.
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影响因子：
3.2
作者：
Ramsey, F. P.
通讯作者：
Ramsey, F. P.
影响因子：
9.6
作者：
Pasipanodya, Jotam G.;Miller, Thaddeus L.;Weis, Stephen E.
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Weis, Stephen E.
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