mGluR5 binding changes during a mismatch negativity task in a multimodal protocol with [(11)C]ABP688 PET/MR-EEG.
mGluR5 binding changes during a mismatch negativity task in a multimodal protocol with [(11)C]ABP688 PET/MR-EEG.
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DOI：
10.1038/s41398-021-01763-3
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发表时间：
2022-01-10
影响因子：
6.8
通讯作者：
Neuner I
中科院分区：
文献类型：
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作者：
Régio Brambilla C;Veselinović T;Rajkumar R;Mauler J;Matusch A;Ruch A;Orth L;Ramkiran S;Sbaihat H;Kaulen N;Khudeish NY;Wyss C;Heekeren K;Kawohl W;Rota Kops E;Tellmann L;Scheins J;Boers F;Neumaier B;Ermert J;Lang M;Stüsgen S;Herzog H;Langen KJ;Shah NJ;Lerche CW;Neuner I
目前，代谢型谷氨酸受体5（mGluR 5）是神经学背景下的几条研究路线的主题，并且作为正电子发射断层扫描（PET）的靶点备受关注。在这里，我们评估了使用[11 C] ABP 688（一种针对mGluR 5变构位点的特异性拮抗剂放射性示踪剂）的可行性，以通过失配负性（MMN）任务评估多巴胺能神经传递的变化，作为同步和同步多模式PET/MR-EEG研究的一部分。我们分析了MMN的影响，通过比较的变化，在非置换结合电位（BPND）之前（基线）和在17名健康受试者的任务期间，通过应用推注/输注协议。解剖和功能区域进行了分析。在任务开始后，在解剖区域（后扣带回皮质和丘脑）和功能网络（楔前叶）中观察到BPND的微小变化。使用肯德尔W值量化效应大小，其为0.3。运动皮层被用作任务的控制区域，没有显示出任何显着的BPND变化。采集条件之间存在显著的ΔBPND。平均而言，解剖学和功能网络中各区域的结合减少分别为-8.6 ± 3.2%和-6.4 ± 0.5%（p ≤ 0.001）。探索性分析表明，MMN任务在海马神经传递中起重要作用，mGluR 5可能间接受这些变化的调节。
Currently, the metabotropic glutamate receptor 5 (mGluR5) is the subject of several lines of research in the context of neurology and is of high interest as a target for positron-emission tomography (PET). Here, we assessed the feasibility of using [11C]ABP688, a specific antagonist radiotracer for an allosteric site on the mGluR5, to evaluate changes in glutamatergic neurotransmission through a mismatch-negativity (MMN) task as a part of a simultaneous and synchronized multimodal PET/MR-EEG study. We analyzed the effect of MMN by comparing the changes in nondisplaceable binding potential (BPND) prior to (baseline) and during the task in 17 healthy subjects by applying a bolus/infusion protocol. Anatomical and functional regions were analyzed. A small change in BPND was observed in anatomical regions (posterior cingulate cortex and thalamus) and in a functional network (precuneus) after the start of the task. The effect size was quantified using Kendall’s W value and was 0.3. The motor cortex was used as a control region for the task and did not show any significant BPND changes. There was a significant ΔBPND between acquisition conditions. On average, the reductions in binding across the regions were - 8.6 ± 3.2% in anatomical and - 6.4 ± 0.5% in the functional network (p ≤ 0.001). Correlations between ΔBPND and EEG latency for both anatomical (p = 0.008) and functional (p = 0.022) regions were found. Exploratory analyses suggest that the MMN task played a role in the glutamatergic neurotransmission, and mGluR5 may be indirectly modulated by these changes.
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影响因子：
10.6
作者：
Chowdhury, Golam M. I.;Behar, Kevin L.;Cho, William;Thomas, Monique A.;Rothman, Douglas L.;Sanacora, Gerard
通讯作者：
Sanacora, Gerard
影响因子：
4.4
作者：
Elmenhorst, David;Mertens, Kristina;Bauer, Andreas
通讯作者：
Bauer, Andreas
影响因子：
6.8
作者：
DeLorenzo, C.;Sovago, J.;Parsey, R. V.
通讯作者：
Parsey, R. V.
影响因子：
7.8
作者：
Del Guerra, Alberto;Ahmad, Salleh;Ziegler, Sibylle
通讯作者：
Ziegler, Sibylle
DOI：
10.1016/j.clinph.2008.11.029
发表时间：
2009-03
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Garrido MI;Kilner JM;Stephan KE;Friston KJ
通讯作者：
Friston KJ