Regulation of auditory plasticity during critical periods and following hearing loss.
Regulation of auditory plasticity during critical periods and following hearing loss.
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DOI：
10.1016/j.heares.2020.107976
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发表时间：
2020-11
期刊：
影响因子：
2.8
通讯作者：
Pyott SJ
中科院分区：
文献类型：
--
作者：
Persic D;Thomas ME;Pelekanos V;Ryugo DK;Takesian AE;Krumbholz K;Pyott SJ
感觉输入对大脑中的神经元组织和感觉地图有深远的影响。在发育关键期（可塑性促进神经回路与外部环境相协调的优化）和成年期（听力损失与耳鸣的产生有关），通过检查听觉输入改变的后果，揭示了调节听觉通路可塑性的机制。在这篇综述中，我们总结了在发育关键期和成年期调节神经元组织和张力图可塑性的分子、细胞和电路水平机制的研究。这些机制在青少年和成人的大脑中都是共享的，并且沿着听觉通路的长度，它们用于调节去抑制网络，突触结构和功能，以及可塑性的结构障碍。可塑性的调节还涉及神经调节回路，它将可塑性与学习和注意力联系起来，以及听觉上行和下行回路，它将听觉皮层和较低的结构联系起来。进一步确定听力损失诱导的可塑性与耳鸣相关的分子和细胞机制的相互作用将继续推进我们对这种疾病的理解，并为其治疗提供新的方法。在CPs期间，大脑可塑性增强，对声音体验敏感。听力丧失后，成人大脑可恢复增强的可塑性。分子、细胞和电路水平的机制调节CP和成体可塑性。听力损失导致的可塑性可能导致耳鸣的出现。改变成人大脑的可塑性可能为耳鸣提供新的治疗方法。
Sensory input has profound effects on neuronal organization and sensory maps in the brain. The mechanisms regulating plasticity of the auditory pathway have been revealed by examining the consequences of altered auditory input during both developmental critical periods—when plasticity facilitates the optimization of neural circuits in concert with the external environment—and in adulthood—when hearing loss is linked to the generation of tinnitus. In this review, we summarize research identifying the molecular, cellular, and circuit-level mechanisms regulating neuronal organization and tonotopic map plasticity during developmental critical periods and in adulthood. These mechanisms are shared in both the juvenile and adult brain and along the length of the auditory pathway, where they serve to regulate disinhibitory networks, synaptic structure and function, as well as structural barriers to plasticity. Regulation of plasticity also involves both neuromodulatory circuits, which link plasticity with learning and attention, as well as ascending and descending auditory circuits, which link the auditory cortex and lower structures. Further work identifying the interplay of molecular and cellular mechanisms associating hearing loss-induced plasticity with tinnitus will continue to advance our understanding of this disorder and lead to new approaches to its treatment. During CPs, brain plasticity is enhanced and sensitive to acoustic experience. Enhanced plasticity can be reinstated in the adult brain following hearing loss. Molecular, cellular, and circuit-level mechanisms regulate CP and adult plasticity. Plasticity resulting from hearing loss may contribute to the emergence of tinnitus. Modifying plasticity in the adult brain may offer new treatments for tinnitus.
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影响因子：
3.3
作者：
Baizer JS;Wong KM;Manohar S;Hayes SH;Ding D;Dingman R;Salvi RJ
通讯作者：
Salvi RJ
影响因子：
5.3
作者：
Blundon, Jay A.;Bayazitov, Ildar T.;Zakharenko, Stanislav S.
通讯作者：
Zakharenko, Stanislav S.
DOI：
10.1177/1073858413482983
发表时间：
2013-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Blundon JA;Zakharenko SS
通讯作者：
Zakharenko SS
影响因子：
2.5
作者：
Buras, ED;Holt, AG;Altschuler, RA
通讯作者：
Altschuler, RA
影响因子：
25
作者：
Baseler, Heidi A.;Gouws, Andre;Morland, Antony B.
通讯作者：
Morland, Antony B.