Ethnicity and Parkinson's Disease: Motor and Nonmotor Features and Disease Progression in Latino Patients Living in Rural California.
Ethnicity and Parkinson's Disease: Motor and Nonmotor Features and Disease Progression in Latino Patients Living in Rural California.
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DOI：
10.1093/gerona/glad016
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发表时间：
2023-07-08
影响因子：
5.1
通讯作者：
Keener, Adrienne M.
中科院分区：
文献类型：
--
作者：
Folle, Aline Duarte;Flores, Marie E. S.;Kusters, Cynthia;Paul, Kimberly C.;Del Rosario, Irish;Zhang, Keren;Ruiz, Cristina;Castro, Emily;Bronstein, Jeff;Ritz, Beate;Keener, Adrienne M.
帕金森病 (PD) 是全球老年人中第二常见的神经退行性疾病。目前，PD 进展的研究主要依赖于非拉丁裔白人 (WNL) 患者。在这里，我们比较了在加州中部农村地区参加一项基于社区的研究的拉丁裔和 WNL 患者的临床概况和 PD 进展情况。 2001 年至 2015 年间，从 3 个县确定了诊断后 5 年内的 PD 患者。在最多 3 次访问期间，运动障碍专家对参与者进行了检查并进行了访谈。我们分析了每次研究访视时 PD 临床特征严重程度的横截面差异，并使用线性混合模型和 Cox 比例风险模型来纵向比较运动、非运动和残疾进展，并评估拉丁裔与 WNL 患者的死亡时间。在 775 名患者中，有 138 名 (18%) 患者自认是拉丁裔，并且诊断时的年龄（63.6 岁 vs 68.9 岁）和死亡年龄（78.6 岁 vs 81.5 岁）都比 WNL 更早。考虑到基线症状严重程度的差异后，与 WNL 患者相比，拉丁裔患者的运动（风险比 [HR] = 1.17 [0.71, 1.94]）和非运动症状进展速度并不快。然而，根据 Hoehn 和 Yahr 的说法，拉丁裔患者进展到残疾阶段的速度比 WNL 更快（HR = 1.81 [1.11, 2.96]）。拉丁裔患者的运动和非运动症状的医疗管理也不如 WNL 患者好。我们对大部分拉丁裔参与者和进展数据进行的帕金森病研究揭示了不同种族的临床特征和进展差异，这可能反映了拉丁裔帕金森病患者的医疗保健获取和结构性社会经济劣势。
Parkinson’s disease (PD) is the second most common neurodegenerative disorder among older adults worldwide. Currently, studies of PD progression rely primarily on White non-Latino (WNL) patients. Here, we compare clinical profiles and PD progression in Latino and WNL patients enrolled in a community-based study in rural Central California. PD patients within 5 years of diagnosis were identified from 3 counties between 2001 and 2015. During up to 3 visits, participants were examined by movement disorders specialists and interviewed. We analyzed cross-sectional differences in PD clinical features severity at each study visit and used linear mixed models and Cox proportional hazards models to compare motor, nonmotor, and disability progression longitudinally and to assess time to death in Latinos compared to WNL patients. Of 775 patients included, 138 (18%) self-identified as Latino and presented with earlier age at diagnosis (63.6 vs 68.9) and death (78.6 vs 81.5) than WNL. Motor (hazard ratio [HR] = 1.17 [0.71, 1.94]) and nonmotor symptoms did not progress faster in Latino versus WNL patients after accounting for differences in baseline symptom severity. However, Latino patients progressed to disability stages according to Hoehn and Yahr faster than WNL (HR = 1.81 [1.11, 2.96]). Motor and nonmotor symptoms in Latino patients were also medically managed less well than in WNL. Our PD study with a large proportion of Latino enrollees and progression data reveals disparities in clinical features and progression by ethnicity that may reflect healthcare access and structural socioeconomic disadvantages in Latino patients with PD.
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DOI：
10.1177/08901171211022677
发表时间：
2022-01
期刊：
American journal of health promotion : AJHP
影响因子：
--
作者：
Heredia NI;Xu T;Lee M;McNeill LH;Reininger BM
通讯作者：
Reininger BM
DOI：
10.2106/jbjs.l.01317
发表时间：
2014-02-19
期刊：
The Journal of bone and joint surgery. American volume
影响因子：
--
作者：
Harris-Hayes, Marcie;Willis, Allison W;Racette, Brad A
通讯作者：
Racette, Brad A
影响因子：
29
作者：
Mantri S;Fullard M;Gray SL;Weintraub D;Hubbard RA;Hennessy S;Willis AW
通讯作者：
Willis AW
影响因子：
9.9
作者：
BUTTERFIELD, PG;VALANIS, BG;NUTT, JG
通讯作者：
NUTT, JG
DOI：
10.3233/jpd-202464
发表时间：
2021
期刊：
Journal of Parkinson's disease
影响因子：
--
作者：
Camerucci E;Stang CD;Hajeb M;Turcano P;Mullan AF;Martin P;Ross OA;Bower JH;Mielke MM;Savica R
通讯作者：
Savica R