The application of a rodent-based Morris water maze (MWM) protocol to an investigation of age-related differences in human spatial learning.
The application of a rodent-based Morris water maze (MWM) protocol to an investigation of age-related differences in human spatial learning.
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DOI：
10.1037/bne0000219
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发表时间：
2017-12
影响因子：
1.9
通讯作者：
Moffat SD
中科院分区：
文献类型：
--
作者：
Zhong JY;Magnusson KR;Swarts ME;Clendinen CA;Reynolds NC;Moffat SD
目前的研究应用了一种基于啮齿动物的Morris水迷宫(MWM)方案来调查年轻人和老年人之间的搜索性能差异。为了研究基于啮齿动物的协议在人类身上是否也可以看到类似的与年龄相关的搜索性能下降，我们实现了一个虚拟MWM(VMWM)，它具有类似于以前在小鼠空间学习研究中使用的MWM的特征。通过使用接近平台的测量，健康的年轻人和老年人在搜索性能上发现了显著的差异。在根据他们的校正累积邻近度(CCProx)值的中位数分裂将老年人分为表现良好和表现不佳的人后，研究发现，就地学习的年龄效应在很大程度上与年轻人和表现不佳的老年人之间的搜索表现差异有关。与年轻人相比，表现不佳的老年人在24个地点试验中的83%以及在没有隐藏平台的情况下评估空间学习的探测器试验中表现出显著更高的接近性值。相比之下，在大多数地点和探测试验中，表现良好的老年人表现出与年轻人相当的搜索表现模式。综上所述，我们的发现表明，表现不佳的老年人的搜索准确率较低，源于策略选择的潜在差异，对任务需求的假设或预期的差异，以及与vMWM搜索性能相关的大脑区域可能存在的潜在功能和/或结构变化。
The current study applied a rodent-based Morris water maze (MWM) protocol to an investigation of search performance differences between young and older adult humans. To investigate whether similar age-related decline in search performance could be seen in humans based on the rodent-based protocol, we implemented a virtual MWM (vMWM) that has characteristics similar to those of the MWM used in previous studies of spatial learning in mice. Through the use of a proximity to platform measure, robust differences were found between healthy young and older adults in search performance. After dividing older adults into good and poor performers based on a median-split of their corrected cumulative proximity (CCProx) values, the age effects in place learning were found to be largely related to search performance differences between the young and poor-performing older adults. When compared to the young, poor-performing older adults exhibited significantly higher proximity values in 83% of 24 place trials and overall in the probe trials that assessed spatial learning in the absence of the hidden platform. In contrast, good-performing older adults exhibited patterns of search performance that were comparable to that of the younger adults in most place and probe trials. Taken together, our findings suggest that the low search accuracy in poor-performing older adults stemmed from potential differences in strategy selection, differences in assumptions or expectations of task demands, as well as possible underlying functional and/or structural changes in the brain regions involved in vMWM search performance.
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影响因子：
1.9
作者：
GALLAGHER, M;BURWELL, RD;BURCHINAL, M
通讯作者：
BURCHINAL, M
影响因子：
3
作者：
Hegarty, M;Richardson, AE;Subbiah, I
通讯作者：
Subbiah, I
影响因子：
2.1
作者：
Antonova, E.;Parslow, D.;Morris, R. G.
通讯作者：
Morris, R. G.
影响因子：
4.2
作者：
Korthauer LE;Nowak NT;Moffat SD;An Y;Rowland LM;Barker PB;Resnick SM;Driscoll I
通讯作者：
Driscoll I
DOI：
10.1089/cpb.2006.9.234
发表时间：
2006-04-01
期刊：
CYBERPSYCHOLOGY & BEHAVIOR
影响因子：
--
作者：
Astur, Robert S.;St Germain, Sarah A.;Stevens, Mike
通讯作者：
Stevens, Mike