Maternal Immunization to Prevent Infectious Diseases in the Neonate or Infant

Maternal Immunization to Prevent Infectious Diseases in the Neonate or Infant
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母亲免疫接种以预防新生儿或婴儿的传染病

DOI:
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发表时间:
1994
影响因子:
3.2
通讯作者:
M. Pichichero
M. Pichichero
中科院分区:
医学4区
文献类型:
--
作者:
R. Insel;M. Amstey;K. Woodin;M. Pichichero

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参考文献

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通过孕妇免疫为幼儿提供被动保护的方法可以绕过新生儿的免疫不成熟问题,避免或推迟婴儿出生一年的主动免疫,并防止感染从母亲传染给新生儿。这种方法的最佳疫苗应诱导高免疫球蛋白G抗体效价,在免疫后迅速达到最高水平,并在保护性水平持续数年,从而在随后的怀孕中提供被动保护。这一方法的具体应用包括世界各地使用破伤风类毒素疫苗进行产妇免疫的做法,以及正在进行的预防婴儿感染b型流感嗜血杆菌、B群链球菌、肺炎球菌、脑膜炎双球菌和人类免疫缺陷病毒的研究。为了确保这一方法的成功,需要解决产妇免疫的文化、社会和法律方面的问题。
Abstract The approach of providing passive protection to young infants by immunizing pregnant women can bypass the problems of immunological immaturity in the neonate, avoid or delay active immunization of the infant in the first year of life, and prevent transmission of an infection from the mother to the neonate. Optimal vaccines for this approach should induce high immunoglobulin G antibody titers that quickly reach their maximum level after immunization and persist at protective levels for several years, thus providing passive protection in subsequent pregnancies. Specific applications of this approach include the worldwide practice of maternal immunization with tetanus toxoid vaccine and ongoing studies of maternal immunization to prevent Haemophilus influenzae type b, group B strepto-coccal, pneumococcal, meningococcal, and human immunodeficiency virus infection in the infant. Addressing the cultural, sociological, and legal aspects of maternal immunization will be required to ensure the success of this approach.
DOI: 10.1097/00006254-198908000-00008
发表时间: 1989-08
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影响因子: --
作者:
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影响因子: --
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母亲用b型流感嗜血杆菌荚膜多糖疫苗进行免疫接种。
DOI: 10.1093/infdis/165-supplement_1-s134
发表时间: 1992
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影响因子: --
作者:
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发表时间: 1983
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影响因子: --
作者:
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通讯作者: Insel,RA