Recovery of memory from infantile amnesia is developmentally constrained.
Recovery of memory from infantile amnesia is developmentally constrained.
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从婴儿期失忆症中恢复记忆受到发育的限制。
DOI：
10.1101/lm.052621.120
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Alberini CM
中科院分区：
文献类型：
--
作者：
Bisaz R;Bessières B;Miranda JM;Travaglia A;Alberini CM
婴儿时期形成的情景记忆很快就会被遗忘，这是一种与婴儿健忘症有关的现象，即成年人无法回忆起早期生活的记忆。在大鼠和小鼠中，婴儿时期的记忆虽然没有表达出来，但实际上是以一种潜在的形式长期储存的。这些潜在的记忆可以在以后的生活中通过某些行为提醒或人工重新激活训练时激活的神经元群来恢复。婴儿记忆的恢复是否受到发育年龄、母亲的存在或刺激呈现的偶然性的限制仍有待确定。在这里，我们表明，在行为再激活后，大鼠的抑制性回避记忆的恢复，包括以暂时不配对的方式暴露于情境（条件刺激[CS]）和脚部刺激（非条件刺激[US]），在US之后立即明显，并且受到再激活出现的发育年龄的限制；然而，它不受母亲的存在或训练和再激活之间的时间间隔的影响。我们得出结论，婴儿记忆恢复的一个限制因素是发育年龄，这表明大脑成熟过程是必要的，以允许恢复“丢失”的婴儿记忆。
Episodic memories formed during infancy are rapidly forgotten, a phenomenon associated with infantile amnesia, the inability of adults to recall early-life memories. In both rats and mice, infantile memories, although not expressed, are actually stored long term in a latent form. These latent memories can be reinstated later in life by certain behavioral reminders or by artificial reactivations of neuronal ensembles activated at training. Whether the recovery of infantile memories is limited by developmental age, maternal presence, or contingency of stimuli presentation remains to be determined. Here, we show that the return of inhibitory avoidance memory in rats following a behavioral reactivation consisting of an exposure to the context (conditioned stimuli [CS]) and footshock (unconditioned stimuli [US]) given in a temporally unpaired fashion, is evident immediately after US and is limited by the developmental age at which the reactivations are presented; however, it is not influenced by maternal presence or the time interval between training and reactivation. We conclude that one limiting factor for infantile memory reinstatement is developmental age, suggesting that a brain maturation process is necessary to allow the recovery of a “lost” infantile memory.
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