Added sugar and sugar-sweetened foods and beverages and the risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study.
Added sugar and sugar-sweetened foods and beverages and the risk of pancreatic cancer in the National Institutes of Health-AARP Diet and Health Study.
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DOI：
10.1093/ajcn/88.2.431
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发表时间：
2008-08
期刊：
影响因子：
--
通讯作者：
Michaud DS
中科院分区：
文献类型：
--
作者：
Bao Y;Stolzenberg-Solomon R;Jiao L;Silverman DT;Subar AF;Park Y;Leitzmann MF;Hollenbeck A;Schatzkin A;Michaud DS
虽然高血糖症，高胰岛素血症和胰岛素抵抗已被假设为参与胰腺癌的发展，结果从流行病学研究添加糖的摄入量是不确定的。我们的目的是调查总添加糖，含糖食品和饮料的消费量是否与胰腺癌风险相关。我们前瞻性地研究了487922名男性和女性，年龄在50-71岁之间，在1995- 1996年没有癌症和糖尿病。每天增加的总膳食糖摄入量（基于美国农业部金字塔服务数据库）通过食物频率问卷进行评估。计算相对风险（RR）和95%置信区间（CI），调整总能量和潜在混杂因素。在平均7.2年的随访中，确定了1258例胰腺癌病例。总添加糖摄入量最低和最高五分位数的中位摄入量分别为12.6 g/天和96.2 g/天。在摄入高总添加糖或含糖食品和饮料的男性或女性中，未观察到胰腺癌的总体风险增加。对于男性和女性，最高与最低摄入量类别的多变量RR为0.85（95% CI：0.68，1.06; P趋势= 0.07）总添加糖，1.01（95%CI：0.82，1.23; P趋势= 0.58）甜食组，0.98（95% CI：0.82，1.18; P趋势= 0.49）对于乳制品甜点，1.12（95% CI：0.91，1.39; P趋势= 0.35），含糖软饮料为1.01（95% CI：0.77，1.31; P趋势= 0.76）。我们的研究结果不支持这样的假设，即添加糖或含糖食品和饮料的消费与胰腺癌的总体风险相关。
Although hyperglycemia, hyperinsulinemia and insulin resistance have been hypothesized to be involved in the development of pancreatic cancer, results from epidemiologic studies on added sugar intake are inconclusive. Our objective was to investigate whether the consumption of total added sugar, sugar-sweetened foods and beverages is associated with pancreatic cancer risk. We prospectively examined 487922 men and women aged 50–71 years and free of cancer and diabetes in 1995–96. Total added dietary sugar intake in teaspoons per day (based on USDA’s Pyramid Servings Database) was assessed with a food frequency questionnaire. Relative risks (RRs) and 95% confidence intervals (CIs) were calculated with adjustment for total energy and potential confounding factors. During an average 7.2 years of follow-up, 1258 incident pancreatic cancer cases were ascertained. The median intakes for the lowest and highest quintiles of total added sugar intake were 12.6 g/day and 96.2 g/day. No overall increased risk of pancreatic cancer was observed in men or women with high intake of total added sugar or sugar-sweetened foods and beverages. For men and women combined, the multivariate RRs of the highest versus lowest intake categories were 0.85 (95% CI: 0.68, 1.06; P trend= 0.07) for total added sugar, 1.01 (95% CI: 0.82,1.23; P trend= 0.58) for sweets, 0.98 (95% CI: 0.82,1.18; P trend= 0.49) for dairy desserts, 1.12 (95% CI: 0.91,1.39; P trend= 0.35) for sugar added to coffee and tea, and 1.01 (95% CI: 0.77,1.31; P trend= 0.76) for sugar-sweetened soft drinks. Our results do not support the hypothesis that consumption of added sugar, or sugar-sweetened foods and beverages is associated with overall risk of pancreatic cancer.
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影响因子：
8.8
作者：
Silverman, DT;Schiffman, M;Everhart, J;Goldstein, A;Lillemoe, KD;Swanson, GM;Schwartz, AG;Brown, LM;Greenberg, RS;Schoenberg, JB;Pottern, LM;Hoover, RN;Fraumeni, JF
通讯作者：
Fraumeni, JF
影响因子：
3.8
作者：
Schernhammer, ES;Hu, FB;Fuchs, CS
通讯作者：
Fuchs, CS
影响因子：
2.3
作者：
Silvera, SAN;Rohan, TE;Miller, AB
通讯作者：
Miller, AB
影响因子：
5
作者：
Schatzkin, A;Subar, AF;Kipnis, V
通讯作者：
Kipnis, V
影响因子：
120.7
作者：
Gapstur, SM;Gann, PH;Dyer, A
通讯作者：
Dyer, A