Hippocampal place cells encode global location but not connectivity in a complex space.
Hippocampal place cells encode global location but not connectivity in a complex space.
复制标题
DOI：
10.1016/j.cub.2021.01.005
复制
发表时间：
2021-03-22
期刊：
影响因子：
--
通讯作者：
Spiers HJ
中科院分区：
文献类型：
--
作者：
Duvelle É;Grieves RM;Liu A;Jedidi-Ayoub S;Holeniewska J;Harris A;Nyberg N;Donnarumma F;Lefort JM;Jeffery KJ;Summerfield C;Pezzulo G;Spiers HJ
灵活的导航依赖于认知的空间地图，被认为是由海马区细胞实现的，海马区细胞是展示特定位置放电的神经元。在互联环境中，最佳导航需要跟踪一个人的位置和子空间之间的可用连接。我们检查了大鼠背侧CA1区细胞是否在四个几何相同的方框中编码环境连接性。老鼠通过推着房式门在箱子之间移动，这种门可以单向或双向锁住。尽管老鼠表现出了环境连通性的知识，但它们的位置细胞对连通性的变化没有反应，它们代表的门口也与其他地方不同。将单元格编码的位置放置在全局参考帧中，每个框具有不同的地图，尽管存在重复的几何图形，但重复的区域最少。这些结果表明，CA1位置细胞提供了一种不明确包括连通性的空间地图。大鼠灵活地在四个房间的迷宫中导航，其中连接性的变化改变了位置细胞的激发区域，单个或整体的位置细胞的活动并不编码连接性的变化，位置细胞可以唯一地映射相同的连接间隔，海马区的位置细胞被认为是空间的“认知地图”的基础。Duvelle和Grives等人。结果表明，老鼠的Place细胞区分四个相连的房间，并学习它们连接性的变化。然而，这种变化不会影响局部细胞的活动，这表明其他大脑区域或机制编码了这一信息。
Flexible navigation relies on a cognitive map of space, thought to be implemented by hippocampal place cells: neurons that exhibit location-specific firing. In connected environments, optimal navigation requires keeping track of one’s location and of the available connections between subspaces. We examined whether the dorsal CA1 place cells of rats encode environmental connectivity in four geometrically identical boxes arranged in a square. Rats moved between boxes by pushing saloon-type doors that could be locked in one or both directions. Although rats demonstrated knowledge of environmental connectivity, their place cells did not respond to connectivity changes, nor did they represent doorways differently from other locations. Place cells coded location in a global reference frame, with a different map for each box and minimal repetitive fields despite the repetitive geometry. These results suggest that CA1 place cells provide a spatial map that does not explicitly include connectivity. Rats flexibly navigate in a four-room maze where connectivity changes Place cell firing fields are not specifically altered by changes in connectivity Single or ensemble place cell activity does not encode changes in connectivity Place cells can uniquely map identical connected compartments Hippocampal place cells are thought to underlie a “cognitive map” of space. Duvelle and Grieves et al. show that the place cells of rats discriminate four connected rooms and rats learn changes in their connectivity. However, such changes do not affect place cell activity, suggesting that other brain regions or mechanisms encode this information.
登录
查看更多内容
影响因子：
7.7
作者：
Dabaghian Y;Brandt VL;Frank LM
通讯作者：
Frank LM
影响因子：
16.6
作者：
Javadi AH;Emo B;Howard LR;Zisch FE;Yu Y;Knight R;Pinelo Silva J;Spiers HJ
通讯作者：
Spiers HJ
DOI：
10.1523/jneurosci.2862-08.2008
发表时间：
2008-10-29
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Fenton AA;Kao HY;Neymotin SA;Olypher A;Vayntrub Y;Lytton WW;Ludvig N
通讯作者：
Ludvig N
影响因子：
2.5
作者：
Fuhs, MC;VanRhoads, SR;Touretzky, DS
通讯作者：
Touretzky, DS
影响因子：
2.7
作者：
Gasser, Julien;de Vasconcelos, Anne Pereira;Cassel, Jean-Christophe
通讯作者：
Cassel, Jean-Christophe