Effect of movement frequency on repetitive finger movements in patients with Parkinson's disease.
Effect of movement frequency on repetitive finger movements in patients with Parkinson's disease.
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DOI：
10.1002/mds.22535
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发表时间：
2009-06-15
影响因子：
8.6
通讯作者：
MacKinnon, Colum
中科院分区：
文献类型：
--
作者：
Stegemoeller, Elizabeth L.;Simuni, Tanya;MacKinnon, Colum
帕金森病（PD）患者重复性手部运动的特点是动作缓慢、运动幅度降低、正在进行的运动中犹豫或停止。目前，导致这些类型的运动性能受损的因素和机制仍然知之甚少。本研究考察了运动频率和药物对PD患者和匹配对照者无约束食指屈曲运动表现的影响。当音调的频率以0.25 Hz的增量从1 Hz增加到3 Hz时，运动与听觉音调同步。根据手指运动学和从食指屈肌和伸肌记录的肌电图（EMG）来量化运动表现。主要发现是PD患者在运动频率达到或超过2hz时表现出运动幅度的急剧减少，运动频率的增加和相位的丧失。这种缺陷在药物治疗后并没有明显改善。相比之下，所有的控制对象都可以同步到3hz。这些发现表明，运动频率是重复性运动中运动不足的主要决定因素，并且可能导致PD患者上肢运动迟缓的临床测试中出现犹豫和运动停止。
Performance of repetitive hand movements in patients with Parkinson's disease (PD) is characterized by slowness, reduced movement amplitude, and hesitation or arrests in ongoing movement. Currently, the factors and mechanisms contributing to impaired performance of these types of movement remain poorly understood. This study examined the effects of movement frequency and medication on the performance of unconstrained index finger flexion movements in patients with PD and matched control subjects. Movements were synchronized with an auditory tone as the frequency of the tone was increased from 1 to 3 Hz in 0.25 Hz increments. Movement performance was quantified based upon finger kinematics and electromyography (EMG) recorded from the index finger flexors and extensors. The principal finding was that patients with PD showed a dramatic reduction in movement amplitude, an increase in movement frequency, and a loss of phase when the movement frequency reached or exceeded 2 Hz. This deficit was not significantly improved with medications. In contrast, all control subjects could synchronize to 3 Hz. These findings show that movement frequency is a major determinant of hypokinesia during repetitive movements and may contribute to hesitations and movement arrest during clinical testing of bradykinesia in the upper limb of patients with PD.
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影响因子：
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