The multiple facets of opioid receptor function: implications for addiction.
The multiple facets of opioid receptor function: implications for addiction.
复制标题
DOI：
10.1016/j.conb.2013.02.005
复制
发表时间：
2013-08
影响因子：
5.7
通讯作者：
Kieffer BL
中科院分区：
文献类型：
--
作者：
Lutz PE;Kieffer BL
Addiction is characterized by altered reward processing, disrupted emotional responses and poor decision-making. Beyond a central role in drug reward, increasing evidence indicate that opioid receptors are more generally involved in all these processes. Recent studies establish the mu opioid receptor as a main player in social reward, which attracts increasing attention in psychiatric research. There is growing interest in blocking the kappa opioid receptor to prevent relapse, and alleviate the negative affect of withdrawal. The delta opioid receptor emerges as a potent mood enhancer, whose involvement in addiction is less clear. All three opioid receptors are likely implicated in addiction-depression comorbidity, and understanding of their roles in cognitive deficits associated to drug abuse is only beginning.
登录
查看更多内容
影响因子：
15.9
作者：
Der-Avakian A;Markou A
通讯作者：
Markou A
影响因子：
6.8
作者：
Cinque C;Pondiki S;Oddi D;Di Certo MG;Marinelli S;Troisi A;Moles A;D'Amato FR
通讯作者：
D'Amato FR
影响因子：
2.9
作者：
Bruchas MR;Land BB;Chavkin C
通讯作者：
Chavkin C
影响因子：
11.1
作者：
Berger, Amy Chang;Whistler, Jennifer L.
通讯作者：
Whistler, Jennifer L.
影响因子：
2.9
作者：
Goody, RJ;Oakley, SM;Kitchen, I
通讯作者：
Kitchen, I