Molecular call and response: the physiology of bacterial small RNAs.

Molecular call and response: the physiology of bacterial small RNAs.
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DOI:
10.1016/j.bbagrm.2011.07.013
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发表时间:
2011-10
影响因子:
4.7
通讯作者:
Vanderpool, Carin K.
Vanderpool, Carin K.
中科院分区:
生物学2区
文献类型:
--
作者:
Richards, Gregory R.;Vanderpool, Carin K.

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细菌小rna (sRNAs)在细胞调控中的重要作用现已得到证实。尽管sRNAs影响基因表达变化的许多不同机制已经被彻底描述,但相对而言,对其生物学作用和对细胞生理学的影响知之甚少。然而,对于一些sRNAs,我们已经深入了解了感知外部环境和内部代谢信号并将其转化为生理结果所需的复杂调控相互作用。在这里,我们回顾了选定的sRNA调控的例子,强调了sRNA表达所需的信号和调控,sRNA调控靶点,以及由此产生的细胞后果。我们强调了参与铁稳态(RyhB, PrrF和FsrA)和碳代谢(Spot 42, CyaR和SgrS)过程调节的sRNAs。
The vital role of bacterial small RNAs (sRNAs) in cellular regulation is now well-established. Although many diverse mechanisms by which sRNAs effect changes in gene expression have been thoroughly described, comparatively less is known about their biological roles and effects on cell physiology. Nevertheless, for some sRNAs, insight has been gained into the intricate regulatory interplay that is required to sense external environmental and internal metabolic cues and turn them into physiological outcomes. Here, we review examples of regulation by selected sRNAs, emphasizing signals and regulators required for sRNA expression, sRNA regulatory targets, and the resulting consequences for the cell. We highlight sRNAs involved in regulation of the processes of iron homeostasis (RyhB, PrrF, and FsrA) and carbon metabolism (Spot 42, CyaR, and SgrS).
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