Lymphocyte phenotype and function in pseudolymphoma associated with Sjögren's syndrome.
Lymphocyte phenotype and function in pseudolymphoma associated with Sjögren's syndrome.
复制标题
干燥综合征相关假性淋巴瘤中的淋巴细胞表型和功能。
DOI：
10.1172/jci110984
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Howell,FV
中科院分区：
文献类型：
--
作者：
Fox,RI;Adamson3rd,TC;Fong,S;Robinson,CA;Morgan,EL;Robb,JA;Howell,FV
对3例假性淋巴瘤合并原发性Sjögren综合征（1(0)SS）患者的淋巴结（LNL）和唾腺淋巴细胞（SGL）进行了单克隆抗体鉴定，结果表明：(a)与抗T细胞抗体OKT4（大于70%）和OKT8（小于20%）反应的T细胞占主导地位（大于80%）；(b)活化抗原的高流行率（大于50%的细胞与OKT10抗体和抗ia抗体反应）；(c)多克隆B细胞（占所有表达kappa或lambda的细胞的8-15%）；(d)通过与不存在于外周血中的抗体B532反应而定义的特异性B细胞亚群。体外功能研究表明，SGL和LNL都为免疫球蛋白合成提供T辅助活性，并且这种活性可以通过抗体OKT4 +补体处理而被消除。SGL和LNL表现出很少的自然杀伤、抗体依赖性细胞毒性或细胞毒性T细胞活性。这些患者的SGL、LNL和外周血淋巴细胞（PBL）核型正常。这些结果表明，1(0)SS的假性淋巴瘤是由非肿瘤性T辅助细胞浸润唾液腺和腺外组织引起的。单克隆抗体是区分假淋巴瘤和非霍奇金（B细胞）淋巴瘤的重要工具，后者在1(0)SS患者中发病率明显升高。我们在假性淋巴瘤组织中发现辅助性T细胞，支持了辅助性T细胞对B细胞的慢性刺激导致恶性B细胞克隆最终逃逸的假设。图1图2图3图4
Lymph node (LNL) and salivary gland lymphocytes (SGL) from three patients with pseudolymphoma and primary Sjögren's syndrome (1(0)SS) were characterized with monoclonal antibodies to demonstrate (a) a predominance of T cells (greater than 80%) reactive with anti-T cell antibodies OKT4 (greater than 70%) and OKT8 (less than 20%); (b) a high prevalence of activation antigens (greater than 50% of cells reactive with antibody OKT10 and anti-Ia antibody); (c) polyclonal B cells (8-15% of all cells expressing kappa or lambda); and (d) a specific B cell subset defined by reactivity with antibody B532 that was not present in their peripheral blood. In vitro functional studies showed that both SGL and LNL provided T helper activity for immunoglobulin synthesis and that this activity could be abolished by treatment with antibody OKT4 plus complement. The SGL and LNL exhibited little natural killer, antibody-dependent cellular cytotoxicity, or cytotoxic T cell activity. Normal karyotype was observed in SGL, LNL, and peripheral blood lymphocytes (PBL) from these patients. These findings indicate that pseudolymphoma in 1(0)SS results from the infiltration of salivary glands and extraglandular tissues by nonneoplastic T helper cells. Monoclonal antibodies provide an important tool to distinguish pseudolymphoma from non-Hodgkins (B cell) lymphomas that have a markedly elevated incidence in 1(0)SS patients. Our finding of T helper cells in pseudolymphoma tissues supports the hypothesis that chronic stimulation of B cells by helper T cells leads to eventual escape of a malignant B cell clone.ImagesFIGURE 1FIGURE 2FIGURE 3FIGURE 4
登录
查看更多内容
由单克隆抗体定义的人类诱导 T 细胞亚群的进一步表征。
影响因子：
4.4
作者：
E. Reinherz;P. Kung;G. Goldstein;S. Schlossman
通讯作者：
S. Schlossman
干燥综合征中的唾液外淋巴异常（网状细胞肉瘤、“假性淋巴瘤”、巨球蛋白血症）。
DOI：
10.1016/0002-9343(67)90148-9
发表时间：
1967
期刊：
The American journal of medicine
影响因子：
--
作者：
N. Talal;L. Sokoloff;W. Barth
通讯作者：
W. Barth
人类 B 细胞淋巴瘤的单克隆性
影响因子：
15.3
作者：
R. Levy;R. Warnke;R. Dorfman;J. Haimovich
通讯作者：
J. Haimovich
DOI：
10.1073/pnas.79.14.4395
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
MEUER, SC;SCHLOSSMAN, SF;REINHERZ, EL
通讯作者：
REINHERZ, EL
T 淋巴细胞克隆的异常迁移。
影响因子：
4.4
作者：
M. Dailey;C. Fathman;E. Butcher;E. Pillemer;I. Weissman
通讯作者：
I. Weissman