Effects of prenatal exposure to sodium arsenite on motor and food-motivated behaviors from birth to adulthood in C57BL6/J mice.
Effects of prenatal exposure to sodium arsenite on motor and food-motivated behaviors from birth to adulthood in C57BL6/J mice.
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DOI：
10.1016/j.ntt.2012.01.001
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发表时间：
2012-03
影响因子：
2.9
通讯作者：
McKay, Naomi
中科院分区：
文献类型：
--
作者：
Markowski, Vincent P.;Reeve, Elizabeth A.;Onos, Kristen;Assadollahzadeh, Mina;McKay, Naomi
饮用砷污染的饮用水与许多癌症和皮肤及血管疾病有关。砷也是一种强效神经系统毒物，流行病学研究表明，儿童在发育早期接触砷会损害其智力功能。本研究的目的是探讨砷对广泛的年龄特异性行为的影响，包括新生儿的基本感觉-运动反应，青少年的自发活动和握力，以及成年人的学习和注意力的操作性措施。妊娠C57 BL 6/J小鼠从妊娠第4天至出生饮用含0、8、25或80 ppm亚砷酸钠的饮用水。砷在每个测试年龄段的雄性和雌性后代中产生了一系列行为障碍。砷最显著的影响是对步态和其他运动反应的发展，包括声惊吓，翻正反射和前肢抓握。这些结果表明，发育砷暴露可以产生其他行为障碍的儿童除了认知障碍。
Consumption of arsenic-contaminated drinking water is associated with numerous cancers and dermal and vascular diseases. Arsenic is also a potent nervous system toxicant and epidemiological studies indicate that intellectual functions in children are compromised following early developmental exposure. This study was designed to examine the effects of arsenic on a broad range of age-specific behaviors including basic sensory-motor responses in neonates, locomotor activity and grip strength in juveniles, and operant measures of learning and attention in adults. Pregnant C57BL6/J mice consumed drinking water containing 0, 8, 25, or 80 ppm sodium arsenite from the fourth day of gestation until birth. Arsenic produced a range of behavioral impairments in male and female offspring at each of the test ages. The most striking effects of arsenic were on the development of gait and other motor responses including acoustic startle, righting reflexes, and forelimb grip. These results suggest that developmental arsenic exposure can produce other behavioral impairments in children in addition to cognitive impairment.
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影响因子：
3.6
作者：
Martinez-Finley, Ebany J.;Ali, Abdul-Mehdi S.;Allan, Andrea M.
通讯作者：
Allan, Andrea M.
DOI：
10.1111/j.1742-7843.2010.00660.x
发表时间：
2011-05-01
影响因子：
3.1
作者：
Markowski, Vincent P.;Currie, Douglas;Wise, John P., Sr.
通讯作者：
Wise, John P., Sr.
影响因子：
8.3
作者：
Calderón, J;Navarro, ME;Díaz-Barriga, F
通讯作者：
Díaz-Barriga, F
影响因子：
3.5
作者：
Delgado, JM;Dufour, L;Jiménez-Capdeville, ME
通讯作者：
Jiménez-Capdeville, ME
影响因子：
3.4
作者：
HEINSBROEK, RPW;VANHAAREN, F;VANDEPOLL, NE
通讯作者：
VANDEPOLL, NE