National borders effectively halt the spread of rabies: the current rabies epidemic in China is dislocated from cases in neighboring countries.
National borders effectively halt the spread of rabies: the current rabies epidemic in China is dislocated from cases in neighboring countries.
复制标题
DOI：
10.1371/journal.pntd.0002039
复制
发表时间：
2013
影响因子：
3.8
通讯作者：
Rayner S
中科院分区：
文献类型：
--
作者：
Guo Z;Tao X;Yin C;Han N;Yu J;Li H;Liu H;Fang W;Adams J;Wang J;Liang G;Tang Q;Rayner S
在过去的15年里，中国狂犬病病例大量复发，造成2.5万多人死亡。最初报告的病例在西南部，但现在几乎每个省都有报告。对病毒在中国的起源和传播进行了几次系统发育调查，但调查疫情对邻国影响的报道很少。因此，我们收集了来自中国和东南亚的核蛋白序列，并研究了它们的系统发育和系统地理关系。结果表明，在东南亚地区，分离株主要根据其地理来源聚集。我们发现了邻国之间零星交换菌株的证据，但似乎导致中国当前疫情的主要菌株尚未输出。这表明，国家地理边界和边境控制在阻止狂犬病从中国传播到邻近地区方面是有效的。我们进一步调查了中国序列的地理结构，发现当前疫情以变异菌株为主，这些变异菌株可能在以前的国内疫情中低水平存在。我们还确定了与基于人类狂犬病病例监测数据的观察结果相一致的高发省份之间的流行病学联系。狂犬病作为一种致命的人畜共患疾病，继续对全球公共卫生构成威胁。继印度之后，中国报告的人类病例数量第二高，自1950年以来已有超过11.75万人死亡，并发生了三次重大疫情。中国仍处于第三次疫情的中期。在这项工作中，我们调查了中国对东南亚狂犬病的影响。我们从东南亚各地分离的样本中收集了核蛋白序列，并研究了它们的系统发育和地理关系。结果表明，东南亚地区狂犬病毒存在明显的地理分布格局，分离株主要根据其地理来源聚集。虽然我们发现了邻国之间零星交换毒株的证据，但导致中国当前疫情的主要毒株似乎并未传播到邻国。我们的研究结果表明，国家地理边界和边境管制是阻止狂犬病从中国传播到邻近地区的有效障碍。我们进一步调查了中国序列的地理结构，发现当前流行的主要是可能从以前的国内流行演变而来的变异菌株。本研究为中国及东南亚地区的狂犬病防治提供了有价值的参考。
China has seen a massive resurgence of rabies cases in the last 15 years with more than 25,000 human fatalities. Initial cases were reported in the southwest but are now reported in almost every province. There have been several phylogenetic investigations into the origin and spread of the virus within China but few reports investigating the impact of the epidemic on neighboring countries. We therefore collected nucleoprotein sequences from China and South East Asia and investigated their phylogenetic and phylogeographic relationship. Our results indicate that within South East Asia, isolates mainly cluster according to their geographic origin. We found evidence of sporadic exchange of strains between neighboring countries, but it appears that the major strain responsible for the current Chinese epidemic has not been exported. This suggests that national geographical boundaries and border controls are effective at halting the spread of rabies from China into adjacent regions. We further investigated the geographic structure of Chinese sequences and found that the current epidemic is dominated by variant strains that were likely present at low levels in previous domestic epidemics. We also identified epidemiological linkages between high incidence provinces consistent with observations based on surveillance data from human rabies cases. Rabies as a fatal zoonotic disease continues to be a public threat to global public health. After India, China reports the second highest number of human cases, with more than 117,500 deaths and three major epidemics since 1950. China remains in the middle of the third epidemic. In this work we investigate the impact of China on rabies in South East (SE) Asia. We collected nucleoprotein sequences from samples isolated throughout SE Asia and investigated their phylogenetic and geographic relationships. Our results indicate that clear geographic patterns exist within rabies virus in SE Asia, with isolates mainly clustered according to their geographic origin. While we found evidence of the sporadic exchange of strains between neighboring countries, the major strain responsible for the current Chinese epidemic does not appear to spread to neighboring countries. Our findings suggest that national geographical boundaries and border controls act as effective barriers to halt the spread of rabies from China into adjacent regions. We further investigated the geographic structure of Chinese sequences and found the current epidemic is dominated by variant strains that likely evolved from previous domestic epidemics. Our study provides valuable insight for rabies control and prevention in China and SE Asia.
登录
查看更多内容
影响因子：
11.8
作者：
Nadin-Davis SA;Turner G;Paul JP;Madhusudana SN;Wandeler AI
通讯作者：
Wandeler AI
影响因子：
8.8
作者：
Meng, Shengli;Xu, Gelin;Rupprecht, Charles E.
通讯作者：
Rupprecht, Charles E.
影响因子：
5
作者：
Nadin-Davis, Susan A.;Sheen, Mary;Wandeler, Alexander I.
通讯作者：
Wandeler, Alexander I.
影响因子：
4.2
作者：
Kuzmin, I. V.;Hughes, G. J.;Rupprecht, C. E.
通讯作者：
Rupprecht, C. E.
雪貂獾狂犬病的起源及其作为中国东南部狂犬病潜在传播源的重要性
影响因子：
3.7
作者：
Liu Y;Zhang S;Wu X;Zhao J;Hou Y;Zhang F;Velasco-Villa A;Rupprecht CE;Hu R
通讯作者：
Hu R