Emergence of Arctic-like rabies lineage in India.

Emergence of Arctic-like rabies lineage in India.
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DOI:
10.3201/eid1301.060702
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发表时间:
2007-01
影响因子:
11.8
通讯作者:
Wandeler AI
Wandeler AI
中科院分区:
医学2区
文献类型:
--
作者:
Nadin-Davis SA;Turner G;Paul JP;Madhusudana SN;Wandeler AI

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目前在印度广泛传播的类北极狂犬病病毒的祖先可能是北极狂犬病谱系出现的原因。 2001 年至 2004 年期间,从印度南部的班加罗尔和海得拉巴市以及印度北部喜马偕尔邦的卡绍利山区回收了 37 份狂犬病感染样本,其中包括 10 份人类唾液和 27 份动物大脑。对这 37 个标本和 1 个档案标本的部分 N 基因核苷酸序列进行系统发育分析,确定了 2 个组,并根据地理起源(北方或南方)划分。将选定的印度病毒与世界范围内发现的代表性狂犬病病毒进行比较表明,所有印度分离株与分布在北美和欧洲北纬地区的环极地狂犬病谱系以及从几个亚洲国家发现的其他病毒密切相关。
Progenitors of Arctic-like rabies viruses, which now circulate extensively in India, may have been responsible for the emergence of the Arctic rabies lineage. A collection of 37 rabies-infected samples, 10 human saliva and 27 animal brain, were recovered during 2001–2004 from the cities of Bangalore and Hyderabad in southern India and from Kasauli, a mountainous region in Himachal Pradesh, northern India. Phylogenetic analysis of partial N gene nucleotide sequences of these 37 specimens and 1 archival specimen identified 2 groups, divided according to their geographic (north or south) origins. Comparison of selected Indian viruses with representative rabies viruses recovered worldwide showed a close association of all Indian isolates with the circumpolar Arctic rabies lineage distributed throughout northern latitudes of North America and Europe and other viruses recovered from several Asian countries.
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