Obstructive and restrictive spirometry from school age to adulthood: three birth cohort studies.
Obstructive and restrictive spirometry from school age to adulthood: three birth cohort studies.
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DOI：
10.1016/j.eclinm.2023.102355
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发表时间：
2024-01
影响因子：
15.1
通讯作者：
Custovic, Adnan
中科院分区：
文献类型：
--
作者：
Ullah, Anhar;Granell, Raquel;Haider, Sadia;Lowe, Lesley;Fontanella, Sara;Arshad, Hasan;Murray, Clare S.;Turner, Steve;Holloway, John W.;Simpson, Angela;Roberts, Graham;Custovic, Adnan
肺活量测量障碍和限制是肺功能受损的两种模式，可预测健康状况不佳。我们研究了这些表型的发展及其从童年到成年早期的转变。在这项研究中，我们分析了1989年至1995年间建立的三个基于英国人口的出生队列的汇总数据。我们将描述性统计、回归模型和数据驱动模型应用于三个基于人口的出生队列的数据，这些队列从童年到成年（中学：8-10岁，n = 8404；青春期：15-18岁，n = 5764；成年早期：20-26岁，n = 4680）至少进行了三次肺活量测定。根据调整后的回归残差，参与者被分配到正常、限制性和阻塞性肺量测定组。我们考虑了两种转变：从8-10岁到15-18岁，从15-18岁到20-26岁。梗阻性表型约占10%，限制性表型约占9%。相当大比例的学龄期肺功能受损儿童（三分之一为阻塞性表现型，一半为限制性表现型）在成年早期得到改善并达到正常和稳定的肺功能。在学龄肺功能正常的人中，小于5%的人在成年后肺功能下降。体重不足的限制性和肥胖的阻塞性参与者不太可能恢复正常。孕妇在怀孕期间吸烟和目前的哮喘诊断增加了持续梗阻和恶化的风险。限制性表型恶化的显著相关因素是首次肺功能评估时较低的BMI。数据驱动的方法确定了阻塞性和限制性群集的类似风险因素。观察各年龄段肺功能的改善和恶化。在儿童时期保持最佳体重和减少孕妇在怀孕期间吸烟可减少肺活量测量阻塞和限制，并改善肺功能。格兰特先生/ S025340/1。
Spirometric obstruction and restriction are two patterns of impaired lung function which are predictive of poor health. We investigated the development of these phenotypes and their transitions through childhood to early adulthood. In this study, we analysed pooled data from three UK population−based birth cohorts established between 1989 and 1995. We applied descriptive statistics, regression modelling and data-driven modelling to data from three population−based birth cohorts with at least three spirometry measures from childhood to adulthood (mid-school: 8–10 years, n = 8404; adolescence: 15–18, n = 5764; and early adulthood: 20–26, n = 4680). Participants were assigned to normal, restrictive, and obstructive spirometry based on adjusted regression residuals. We considered two transitions: from 8–10 to 15–18 and from 15–18 to 20–26 years. Obstructive phenotype was observed in ∼10%, and restrictive in ∼9%. A substantial proportion of children with impaired lung function in school age (between one third in obstructive and a half in restricted phenotype) improved and achieved normal and stable lung function to early adulthood. Of those with normal lung function in school-age, <5% declined to adulthood. Underweight restrictive and obese obstructive participants were less likely to transit to normal. Maternal smoking during pregnancy and current asthma diagnosis increased the risk of persistent obstruction and worsening. Significant associate of worsening in restrictive phenotypes was lower BMI at the first lung function assessment. Data-driven methodologies identified similar risk factors for obstructive and restrictive clusters. The worsening and improvement in obstructive and restrictive spirometry were observed at all ages. Maintaining optimal weight during childhood and reducing maternal smoking during pregnancy may reduce spirometry obstruction and restriction and improve lung function. Grant MR/S025340/1.
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DOI：
10.1164/rccm.202108-1821oc
发表时间：
2022-04-15
影响因子：
24.7
作者：
Haider, Sadia;Granell, Raquel;Curtin, John;Fontanella, Sara;Cucco, Alex;Turner, Stephen;Simpson, Angela;Roberts, Graham;Murray, Clare S.;Holloway, John W.;Devereux, Graham;Cullinan, Paul;Arshad, Syed Hasan;Custovic, Adnan
通讯作者：
Custovic, Adnan
影响因子：
10
作者：
Guerra S;Sherrill DL;Venker C;Ceccato CM;Halonen M;Martinez FD
通讯作者：
Martinez FD
影响因子：
10
作者：
Hayatbakhsh, M. R.;Sadasivam, S.;O'Callaghan, M. J.
通讯作者：
O'Callaghan, M. J.
影响因子：
8.9
作者：
Huang，Li;Wang，Sen-Te;Lee，Yungling L.
通讯作者：
Lee，Yungling L.
影响因子：
76.2
作者：
Dharmage, Shyamali C.;Bui, Dinh S.;Perret, Jennifer L.
通讯作者：
Perret, Jennifer L.