Integrated internal ion-gated organic electrochemical transistors for stand-alone conformable bioelectronics.
Integrated internal ion-gated organic electrochemical transistors for stand-alone conformable bioelectronics.
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DOI：
10.1038/s41563-023-01599-w
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发表时间：
2023-10
期刊：
影响因子：
41.2
通讯作者：
Khodagholy, Dion
中科院分区：
文献类型：
--
作者：
Cea, Claudia;Zhao, Zifang;Wisniewski, Duncan J.;Spyropoulos, George D.;Polyravas, Anastasios;Gelinas, Jennifer N.;Khodagholy, Dion
有机电子器件可以是生物相容的和适形的，从而增强与组织接合的能力。然而，到目前为止，速度和集成度的限制使得必须依赖硅基技术来进行高级处理，数据传输和设备供电。在这里，我们创建一个独立的，舒适的，完全有机的生物电子设备能够实现这些功能。该器件，垂直内部离子门控有机电化学晶体管（vIGT），是基于一个晶体管架构，结合了垂直通道和小型化的水化接入管道，使兆赫兹信号范围内的密集封装的集成阵列在没有串扰的操作。这些晶体管在生理介质中表现出长期稳定性，并用于生成高性能集成电路。我们利用垂直内部离子门控有机电化学晶体管的高速和低压操作来开发交流供电的整合电路，以获取和无线通信信号。由此产生的独立设备被植入自由移动的啮齿动物体内，以获取、处理和传输神经生理学大脑信号。这种完全有机的设备有可能将生物电子学的实用性和可访问性扩展到广泛的临床和社会应用。有机电子器件增强了生物相容性，但必须依赖硅基技术来提高有限的速度和集成度。通过创建在生理介质中具有高电子性能、可扩展性、稳定性和顺应性的独立的、无线的、顺应性的、完全有机的生物电子设备来克服该问题。
Organic electronics can be biocompatible and conformable, enhancing the ability to interface with tissue. However, the limitations of speed and integration have, thus far, necessitated reliance on silicon-based technologies for advanced processing, data transmission and device powering. Here we create a stand-alone, conformable, fully organic bioelectronic device capable of realizing these functions. This device, vertical internal ion-gated organic electrochemical transistor (vIGT), is based on a transistor architecture that incorporates a vertical channel and a miniaturized hydration access conduit to enable megahertz-signal-range operation within densely packed integrated arrays in the absence of crosstalk. These transistors demonstrated long-term stability in physiologic media, and were used to generate high-performance integrated circuits. We leveraged the high-speed and low-voltage operation of vertical internal ion-gated organic electrochemical transistors to develop alternating-current-powered conformable circuitry to acquire and wirelessly communicate signals. The resultant stand-alone device was implanted in freely moving rodents to acquire, process and transmit neurophysiologic brain signals. Such fully organic devices have the potential to expand the utility and accessibility of bioelectronics to a wide range of clinical and societal applications. Organic electronic devices enhance biocompatibility, but have to rely on silicon-based technologies to improve limited speed and integration. This problem is overcome by creating a stand-alone, wireless, conformable, fully organic bioelectronic device with high electronic performance, scalability, stability and conformability in physiologic media.
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影响因子：
16.6
作者：
Inal S;Malliaras GG;Rivnay J
通讯作者：
Rivnay J
DOI：
10.1126/science.aan6203
发表时间：
2017-10-20
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Khodagholy D;Gelinas JN;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
29
作者：
Krook-Magnuson E;Gelinas JN;Soltesz I;Buzsáki G
通讯作者：
Buzsáki G
影响因子：
16.6
作者：
Rivnay J;Inal S;Collins BA;Sessolo M;Stavrinidou E;Strakosas X;Tassone C;Delongchamp DM;Malliaras GG
通讯作者：
Malliaras GG
影响因子：
56.9
作者：
Minev, Ivan R.;Musienko, Pavel;Lacour, Stephanie P.
通讯作者：
Lacour, Stephanie P.