Adaptive evolution of genes involved in the regulation of germline stem cells in Drosophila melanogaster and D. simulans.

Adaptive evolution of genes involved in the regulation of germline stem cells in Drosophila melanogaster and D. simulans.
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DOI:
10.1534/g3.114.015875
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发表时间:
2015-02-09
期刊:
G3 (Bethesda, Md.)
影响因子:
--
通讯作者:
Aquadro CF
Aquadro CF
中科院分区:
其他
文献类型:
--
作者:
Flores HA;DuMont VL;Fatoo A;Hubbard D;Hijji M;Barbash DA;Aquadro CF

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不同类群的群体遗传学和比较分析表明,许多与生殖有关的基因正在适应性地进化。两个涉及生殖系干细胞调控的基因,大理石袋(bam)和良性生殖腺细胞瘤(bgcn),先前已被证明在黑腹果蝇和果蝇中经历反复的适应性进化。simulans。在这里,我们报告了一个群体遗传学调查的8个额外的基因参与生殖干细胞调控在D。melanogaster和D.在使用0.05的错误发现率对多个测试进行校正后,揭示所有八个这些基因的模拟程序在至少一个测试和一个物种中拒绝了中性进化模型。这些基因在生殖系干细胞的调控中发挥着不同的作用,这表明响应于几种进化压力的正选择可能会驱动这些基因的适应性进化。
Population genetic and comparative analyses in diverse taxa have shown that numerous genes involved in reproduction are adaptively evolving. Two genes involved in germline stem cell regulation, bag of marbles (bam) and benign gonial cell neoplasm (bgcn), have been shown previously to experience recurrent, adaptive evolution in both Drosophila melanogaster and D. simulans. Here we report a population genetic survey on eight additional genes involved in germline stem cell regulation in D. melanogaster and D. simulans that reveals all eight of these genes reject a neutral model of evolution in at least one test and one species after correction for multiple testing using a false-discovery rate of 0.05. These genes play diverse roles in the regulation of germline stem cells, suggesting that positive selection in response to several evolutionary pressures may be acting to drive the adaptive evolution of these genes.
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