3D printing PLGA: a quantitative examination of the effects of polymer composition and printing parameters on print resolution.
3D printing PLGA: a quantitative examination of the effects of polymer composition and printing parameters on print resolution.
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DOI：
10.1088/1758-5090/aa6370
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发表时间：
2017-04-12
期刊：
影响因子：
9
通讯作者：
Fisher JP
中科院分区：
文献类型：
--
作者：
Guo T;Holzberg TR;Lim CG;Gao F;Gargava A;Trachtenberg JE;Mikos AG;Fisher JP
In the past few decades, 3D printing has played a significant role in fabricating scaffolds with consistent, complex structure that meet patient-specific needs in future clinical applications. Although many studies have contributed to this emerging field of additive manufacturing, which includes material development and computer-aided scaffold design, current quantitative analyses do not correlate material properties, printing parameters, and printing outcomes to a great extent. A model that correlates these properties has tremendous potential to standardize 3D printing for tissue engineering and biomaterial science. In this study, we printed poly(lactic-co-glycolic acid) (PLGA) utilizing a direct melt extrusion technique without additional ingredients. We investigated PLGA with various lactic acid: glycolic acid (LA:GA) molecular weight ratios and end caps to demonstrate the dependence of the extrusion process on the polymer composition. Micro-computed tomography was then used to evaluate printed scaffolds containing different LA:GA ratios, composed of different fiber patterns, and processed under different printing conditions. We built a statistical model to reveal the correlation and predominant factors that determine printing precision. Our model showed a strong linear relationship between the actual and predicted precision under different combinations of printing conditions and material compositions. This quantitative examination establishes a significant foreground to 3D print biomaterials following a systematic fabrication procedure. Additionally, our proposed statistical models can be applied to couple specific biomaterials and 3D printing applications for patient implants with particular requirements.
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影响因子：
5
作者：
Makadia HK;Siegel SJ
通讯作者：
Siegel SJ
影响因子：
14
作者：
Li, WJ;Tuli, R;Tuan, RS
通讯作者：
Tuan, RS
影响因子：
4.9
作者：
Chew, Sue Anne;Arriaga, Marco A.;Hinojosa, Victor A.
通讯作者：
Hinojosa, Victor A.
影响因子：
56.9
作者：
LANGER, R;VACANTI, JP
通讯作者：
VACANTI, JP
DOI：
10.1002/adma.201503691
发表时间：
2015-12-22
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Behrens AM;Lee NG;Casey BJ;Srinivasan P;Sikorski MJ;Daristotle JL;Sandler AD;Kofinas P
通讯作者：
Kofinas P