Adult bone marrow-derived hemangioblasts, endothelial cell progenitors, and EPCs.
Adult bone marrow-derived hemangioblasts, endothelial cell progenitors, and EPCs.
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成人骨髓来源的成血管细胞、内皮细胞祖细胞和 EPC。
DOI：
10.1016/s0070-2153(04)64007-5
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Schatteman,GinaC
中科院分区：
文献类型：
--
作者：
Schatteman,GinaC
八.动员九.骨髓诱导的缺血组织X的功能改善。我们准备好进行人体试验了吗？XI。展望未来确认参考早在血岛的存在被证实之前，对血岛的研究就表明胚胎中存在血管母细胞，这一点被广泛接受。相比之下，尽管至少早在1932年就出现了成体血管母细胞的证据，但直到最近，人们通常认为没有成体血管母细胞。在过去的十年里，这些观点发生了变化，现在人们普遍接受的是，骨髓细胞或其后代可以并确实具有成人血管母细胞的功能。本章将研究骨髓来源的血管母细胞和内皮细胞前体细胞(血管母细胞)的基本生物学，以及这些成年细胞与它们的胚胎对应细胞的关系。还将讨论EVorts定义内皮细胞前体表型的方法，尽管到目前为止，对于确定的成体表型还没有一致意见，可能是因为有多种表型，而且细胞是可塑性的。此外，还研究了骨髓来源的细胞在血管内稳态和修复中的假定作用，包括它们分化和直接促进血管修复的能力，以及通过分泌促血管生成因子促进血管生长的能力。最后，使用骨髓细胞作为治疗工具将是
VIII. Mobilization IX. Bone Marrow-Induced Functional Improvements in Ischemic Tissue X. Are We Ready for Human Trials? XI. Looking to the Future Acknowledgments ReferencesLong before their existence was proven, work with blood islands pointed to the existence of hemangioblasts in the embryo, and it was widely accepted that such cells existed. In contrast, though evidence for adult hemangioblasts appeared at least as early as 1932, until quite recently, it was commonly assumed that there were no adult hemangioblasts. Over the past decade, these views have changed, and it is now generally accepted that a subset of bone marrow cells or their progeny can and do function as adult hemangioblasts. This chapter will examine the basic biology of bone marrow-derived hemangioblasts and endothelial cell progenitors (angioblasts) and the relationship of these adult cells to their embryonic counterparts. EVorts to define the endothelial cell progenitor phenotype will also be discussed, though to date, there is no consensus on the definitive adult phenotype, probably because there are multiple phenotypes and because the cells are plastic. Also examined are the putative roles of bone marrow-derived cells in vascular homeostasis and repair, including both their ability to diVerentiate and contribute directly to vascular repair, as well as to promote vascular growth by secreting pro-angiogenic factors. Finally, the use of bone marrow cells as therapeutic tools will be
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影响因子：
20.3
作者：
Brasel, K;McKenna, HJ;Lyman, SD
通讯作者：
Lyman, SD
DOI：
10.1007/s004290050237
发表时间：
1999-05-01
期刊：
ANATOMY AND EMBRYOLOGY
影响因子：
--
作者：
Bittner, RE;Schöfer, C;Wachtler, F
通讯作者：
Wachtler, F
影响因子：
20.3
作者：
Cogle, CR;Wainman, DA;Scott, EW
通讯作者：
Scott, EW
DOI：
10.1073/pnas.0536882100
发表时间：
2003-03-04
影响因子：
11.1
作者：
Zhao, Y;Glesne, D;Huberman, E
通讯作者：
Huberman, E
影响因子：
3.4
作者：
M. J. Yusta;Manuel A. González;N. Pavón;A. B. Martín;R. de la Fuente;J. García;F. de Pablo;R. Moratalla;A. Bernad;C. Vicario
通讯作者：
C. Vicario