Detailed expression profile of all six Glypicans and their modifying enzyme Notum during chick embryogenesis and their role in dorsal-ventral patterning of the neural tube.
Detailed expression profile of all six Glypicans and their modifying enzyme Notum during chick embryogenesis and their role in dorsal-ventral patterning of the neural tube.
复制标题
鸡胚胎发生过程中所有六种磷脂酰肌醇蛋白聚糖及其修饰酶 Notum 的详细表达谱及其在神经管背腹模式中的作用。
作者：
Saad K
脊椎动物的发育是由分泌的信号分子精心策划的，这些信号分子调节早期胚胎发生期间的细胞行为和细胞命运决定。关键信号传导分子的活性包括刺猬蛋白、骨形态发生蛋白和Wnt家族的成员，由磷脂酰肌醇蛋白聚糖（GPI连接的多肽家族）调节。磷脂酰肌醇蛋白聚糖促进或抑制信号分子的作用，并增加了一层复杂性，需要理解，以充分破译调节早期脊椎动物发育的过程。在这里，我们提出了一个详细的表达谱的所有六个Glypicans和他们的修饰酶Notum在鸡胚胎发生。我们的研究结果强烈表明，这些蛋白质有许多尚未发现的作用，在早期胚胎发生过程中发挥。最后，我们已经采取了一种实验方法来研究它们在胚胎关键结构-神经管的形成过程中的作用。特别是，我们发现Notum的过度表达导致了这种结构的背侧化。
Vertebrate development is orchestrated by secreted signalling molecules that regulate cell behaviour and cell fate decisions during early embryogenesis. The activity of key signalling molecules including members of Hedgehog, Bone Morphogenetic Proteins and Wnt families are regulated by Glypicans, a family of GPI linked polypeptides. Glypicans either promote or inhibit the action of signalling molecules and add a layer of complexity that needs to be understood in order to fully decipher the processes that regulate early vertebrate development. Here we present a detailed expression profile of all six Glypicans and their modifying enzyme Notum during chick embryogenesis. Our results strongly suggest that these proteins have many as yet undiscovered roles to play during early embryogenesis. Finally, we have taken an experimental approach to investigate their role during the patterning of a key embryonic structure - the neural tube. In particular, we show that over-expression of Notum leads to the dorsalisation of this structure.
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