The Gateway Reflex, a Novel Neuro-Immune Interaction for the Regulation of Regional Vessels.
The Gateway Reflex, a Novel Neuro-Immune Interaction for the Regulation of Regional Vessels.
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DOI：
10.3389/fimmu.2017.01321
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发表时间：
2017
影响因子：
7.3
通讯作者：
Murakami M
中科院分区：
文献类型：
--
作者：
Tanaka Y;Arima Y;Kamimura D;Murakami M
门户反射是一种新的现象，它解释了免疫细胞如何绕过血脑屏障渗透到中枢神经系统(CNS)并引发神经炎症。到目前为止，已经发现了四个门户反射的例子，每个例子都由唤起反射的刺激来描述。重力、电、疼痛和压力都被发现在中枢神经系统的特定区域建立了通道。门户反射是四种反射中最新发现的一种，也被证明通过对中枢神经系统的作用而扰乱了外周器官的动态平衡。这些反射为控制局部神经炎症和器官功能提供了新的治疗靶点。每个通道反射由不同的神经激活激活，并在中枢不同区域引起炎症反应。因此，从理论上讲，单独操作每一种方法是可能的，为控制局部神经炎和周围器官的动态平衡提供了一种新的治疗策略。
The gateway reflex is a new phenomenon that explains how immune cells bypass the blood–brain barrier to infiltrate the central nervous system (CNS) and trigger neuroinflammation. To date, four examples of gateway reflexes have been discovered, each described by the stimulus that evokes the reflex. Gravity, electricity, pain, and stress have all been found to create gateways at specific regions of the CNS. The gateway reflex, the most recently discovered of the four, has also been shown to upset the homeostasis of organs in the periphery through its action on the CNS. These reflexes provide novel therapeutic targets for the control of local neuroinflammation and organ function. Each gateway reflex is activated by different neural activations and induces inflmammation at different regions in the CNS. Therefore, it is theoretically possible to manipulate each independently, providing a novel therapeutic strategy to control local neuroinflammation and peripheral organ homeostasis.
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影响因子：
5.8
作者：
Ehde, DM;Gibbons, LE;Kraft, GH
通讯作者：
Kraft, GH
影响因子：
7.3
作者：
Bellavance MA;Rivest S
通讯作者：
Rivest S
影响因子：
3.3
作者：
De Bosscher, K;Vanden Berghe, W;Haegeman, G
通讯作者：
Haegeman, G
影响因子：
7.7
作者：
Arima Y;Kamimura D;Atsumi T;Harada M;Kawamoto T;Nishikawa N;Stofkova A;Ohki T;Higuchi K;Morimoto Y;Wieghofer P;Okada Y;Mori Y;Sakoda S;Saika S;Yoshioka Y;Komuro I;Yamashita T;Hirano T;Prinz M;Murakami M
通讯作者：
Murakami M
DOI：
10.1084/jem.20120571
发表时间：
2012-06-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Andersson U;Tracey KJ
通讯作者：
Tracey KJ