Individual differences in the balance of GABA to glutamate in pFC predict the ability to select among competing options.
Individual differences in the balance of GABA to glutamate in pFC predict the ability to select among competing options.
复制标题
PFC中GABA与谷氨酸平衡的个体差异预测了在竞争选择中选择的能力。
DOI：
10.1162/jocn_a_00655
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发表时间：
2014-11
影响因子：
3.2
通讯作者：
Banich MT
中科院分区：
文献类型：
--
作者：
de la Vega A;Brown MS;Snyder HR;Singel D;Munakata Y;Banich MT
当面对众多选项时，每个人选择一个项目或回答的能力差异很大。在这里，我们调查这些个体差异的神经基础。使用磁共振波谱，我们发现，抑制性与兴奋性神经递质在pFC的平衡预测的能力，在两个语言生产任务的任务相关的选项中进行选择。一个人的GABA相对于谷氨酸的浓度越高，他或她就能越快地从竞争选项中选择一个相关的词。这一结果与我们对此任务的计算建模一致[Snyder，H. R.，Hutchison，N.，尼胡斯，E.，Curran，T.，Banich，M. T.，奥莱利河C.的方法，Neural inhibition enables selection during language processing.美国国家科学院院刊，107，16483-16488，2010]，其预测pFC中更大的净抑制增加了解决任务相关选项之间竞争的效率。此外，与GABA/谷氨酸比率的关联是特定的选择，并没有观察到一般的执行功能能力。这些发现首次将pFC中兴奋性和抑制性神经传递的平衡与执行功能的特定方面联系起来。
Individuals vary greatly in their ability to select one item or response when presented with a multitude of options. Here we investigate the neural underpinnings of these individual differences. Using magnetic resonance spectroscopy, we found that the balance of inhibitory versus excitatory neurotransmitters in pFC predicts the ability to select among task-relevant options in two language production tasks. The greater an individual’s concentration of GABA relative to glutamate in the lateral pFC, the more quickly he or she could select a relevant word from among competing options. This outcome is consistent with our computational modeling of this task [Snyder, H. R., Hutchison, N., Nyhus, E., Curran, T., Banich, M. T., O’Reilly, R. C., et al. Neural inhibition enables selection during language processing. Proceedings of the National Academy of Sciences, U.S.A., 107, 16483–16488, 2010], which predicts that greater net inhibition in pFC increases the efficiency of resolving competition among task-relevant options. Moreover, the association with the GABA/glutamate ratio was specific to selection and was not observed for executive function ability in general. These findings are the first to link the balance of excitatory and inhibitory neural transmission in pFC to specific aspects of executive function.
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DOI：
10.1016/j.cub.2010.09.003
发表时间：
2010-10-12
期刊：
Current biology : CB
影响因子：
--
作者：
Boy F;Evans CJ;Edden RA;Singh KD;Husain M;Sumner P
通讯作者：
Sumner P
影响因子：
19.9
作者：
Munakata, Yuko;Herd, Seth A.;Chatham, Christopher H.;Depue, Brendan E.;Banich, Marie T.;O'Reilly, Randall C.
通讯作者：
O'Reilly, Randall C.
影响因子：
7.6
作者：
Iyengar, SS;Lepper, MR
通讯作者：
Lepper, MR
影响因子：
2.9
作者：
Frank, Michael J.;Loughry, Bryan;O'Reilly, Randall C.
通讯作者：
O'Reilly, Randall C.
影响因子：
3.4
作者：
Novick JM;Kan IP;Trueswell JC;Thompson-Schill SL
通讯作者：
Thompson-Schill SL