Modulation of MHC isoforms in functionally overloaded and exercised rat plantaris fibers.
Modulation of MHC isoforms in functionally overloaded and exercised rat plantaris fibers.
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功能超载和运动的大鼠跖肌纤维中 MHC 同种型的调节。
DOI：
10.1152/jappl.1997.83.1.280
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Edgerton,VR
中科院分区：
文献类型：
--
作者：
Roy,RR;Talmadge,RJ;Fox,K;Lee,M;Ishihara,A;Edgerton,VR
罗伊，罗兰R.，Robert J. Talmadge，Kenneth Fox，Michael Lee，阿基石原，和V. Reggie埃杰顿.在功能过载和运动的大鼠跖肌纤维中MHC同种型的调节.应用生理学杂志83（1）：280-290，1997.-本文研究了1周和10周功能超负荷（FO）加（FOTr）和不加（FOTr）耐力跑台训练对大鼠跖肌肌球蛋白重链（MHC）组成的影响。FO治疗1周和10周后，与年龄匹配的对照组相比，FO组和FOTr组大鼠的足底重量分别增加了22%和56%，分别增加了37%和94%。在第1周，FO（39和44%）和FOTr（70和87%）大鼠的纯I型和纯IIa型MHC纤维肥大。到10周时，两个FO组中占取样纤维>5%的所有纤维类型均显示肥大反应。一个星期的FO增加的百分比混合（包含I型和IIa型MHC）纤维和含有胚胎MHC的纤维。到10周时，两个FO组中纯I型MHC纤维的百分比均为40%，而对照组为15%，含有胚胎MHC的纤维的百分比与对照组相似。十二烷基硫酸钠-聚丙烯酰胺凝胶电泳分析表明，增加I型MHC和减少IIb型MHC在两个FO组在10周，而在1周时观察到的变化不大。这些数据与慢性超负荷肌肉的肥大和从快到慢的MHC亚型的转化是一致的。本研究中采用的每日耐力跑步机训练（1.6 km/天; 10%坡度）所施加的额外过载导致更大的肥大反应，但似乎对MHC适应性的影响最小。
Roy, Roland R., Robert J. Talmadge, Kenneth Fox, Michael Lee, Aki Ishihara, and V. Reggie Edgerton.Modulation of MHC isoforms in functionally overloaded and exercised rat plantaris fibers.J. Appl. Physiol.83(1): 280–290, 1997.—The effects of 1 and 10 wk of functional overload (FO) of the rat plantaris with (FOTr) and without daily endurance treadmill training on its myosin heavy chain (MHC) composition were studied. After 1 and 10 wk of FO, plantaris mass was 22 and 56% greater in FO and 37 and 94% greater, respectively, in FOTrrats compared with age-matched controls. At 1 wk, pure type I and pure type IIa MHC fibers were hypertrophied in FO (39 and 44%) and FOTr(70 and 87%) rats. By 10 wk all fiber types comprising >5% of the fibers sampled showed a hypertrophic response in both FO groups. One week of FO increased the percentage of hybrid (containing both type I and type IIa MHC) fibers and of fibers containing embryonic MHC. By 10 wk, the percentage of pure type I MHC fibers was ∼40% in both FO groups compared with 15% in controls, and the percentage of fibers containing embryonic MHC was similar to that in controls. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analyses showed an increase in type I MHC and a decrease in type IIb MHC in both FO groups at 10 wk, whereas little change was observed at 1 wk. These data are consistent with hypertrophy and transformation from faster to slower MHC isoforms in chronically overloaded muscles. The additional overload imposed by daily endurance treadmill training employed in this study (1.6 km/day; 10% incline) results in a larger hypertrophic response but appears to have a minimal effect on the MHC adaptations.
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DOI：
10.1016/0020-711x(93)90519-k
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期刊：
The International journal of biochemistry
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DOI：
10.1152/jappl.1996.80.4.1296
发表时间：
1996
期刊：
Journal of applied physiology (Bethesda, Md. : 1985)
影响因子：
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作者：
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DOI：
10.1159/000421553
发表时间：
1992
期刊：
Acta physiologica Scandinavica
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DOI：
10.1042/bj2570691
发表时间：
1989
期刊：
The Biochemical journal
影响因子：
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作者：
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