Transforming genes among three different oncogenic subgroups of human adenoviruses have similar replicative functions.
Transforming genes among three different oncogenic subgroups of human adenoviruses have similar replicative functions.
复制标题
人类腺病毒的三个不同致癌亚群之间的转化基因具有相似的复制功能。
DOI：
10.1128/jvi.39.1.300-305.1981
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发表时间：
1981
影响因子：
5.4
通讯作者：
Chinnadurai,G
中科院分区：
文献类型：
--
作者：
Brusca,JS;Chinnadurai,G
We have examined the functional similarity of the transforming genes for replicative functions among three different subgroups of human adenoviruses (A, B, and C), using mutant complementation as an assay. A host range deletion mutant (dl201.2) of Ad2 (nononcogenic subgroup C) lacking about 5% of the viral DNA covering two early gene blocks (E1a and E1b) involved in cellular transformation was isolated and tested for its ability to replicate in nonpermissive KB cells in the presence of Ad7 (weakly oncogenic group B) or ad12 (highly oncogenic group A). The complementation of the mutant defect was demonstrated by cleaving the viral DNA extracted from mixed infected cells or the DNA extracted from purified virions from mixed infected cells with restriction endonuclease BamHI, which produces a different cleavage pattern with the DNA of each serotype. It was found that the defects in E1a plus E1b of dl201.2 could be complemented by Ad7 and Ad12, indicating that these genes in Ad2, Ad7, and Ad12 have similar functions during productive infection.
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影响因子：
11.2
作者：
Lu X;Kang Y
通讯作者：
Kang Y
影响因子：
11.2
作者：
G. Ostrander;K. Cheng;J. Wolf;M. Wolfe
通讯作者：
G. Ostrander;K. Cheng;J. Wolf;M. Wolfe
患有恶性和良性乳腺肿瘤的患者的血清和尿液中存在免疫抑制“p15E 样”因子
影响因子：
4.6
作者：
H. Stöger;H. Stöger;M. Wilders;H. Samonigg;M. Schmid;T. Bauernhofer;A. Tiran;M. Tas;H. Drexhage
通讯作者：
H. Drexhage
正常和转化大鼠细胞中 IAP 相关转录物的检测。
DOI：
--
发表时间：
1990
期刊：
Biochemical and Biophysical Research Communications - BBRC
影响因子：
--
作者：
I. Djaffar;L. Dianoux;S. Leibovich;L. Kaplan;R. Emanoil;J. Périès
通讯作者：
J. Périès
疱疹病毒和幸运肿瘤。
影响因子：
11.2
作者：
A. Granoff
通讯作者：
A. Granoff