Prognostic Value of a New Marker of Ventricular Repolarization in Cirrhotic Patients.
Prognostic Value of a New Marker of Ventricular Repolarization in Cirrhotic Patients.
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DOI：
10.5935/abc.20160181
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发表时间：
2016-12
影响因子：
2.6
通讯作者：
Terra C
中科院分区：
文献类型：
--
作者：
Salgado AA;Barbosa PRB;Ferreira AG;Reis CASS;Terra C
关于体表心电图心室复极变化与肝硬化严重程度的关系仍有争议。探讨心肌梗死患者心室复极相关指标与心肌梗死临床严重程度的关系。我们选择了79名肝硬化患者，根据Child-Pugh-Turcotte标准（Child A、B和C）进行分类。我们测量了QT间期和校正QT间期（QTc），以及T波峰值和终点之间的间期（TpTe），并确定了12导联心电图中的最小值、最大值和平均值。我们还计算了QT（DQT）和QTc（DQTc）间期的离散度。在12个月的临床随访中，9例受试者接受了肝移植（Child A：0 [0%]; Child B：6 [23.1%]; Child C：3 [18.8%]; p = 0.04），12例死亡（Child A：3 [12.0%]; Child B：4 [15.4%]; Child C：5 [31.3%]; p = 0.002）。在QT、QTc、TpTe、DQT和DQTc间期的最小值、最大值和平均值方面，未观察到两组间的显著差异。最小TpTe间期≤ 50 ms是死亡或肝移植复合终点的预测因子，灵敏度为90%，特异性为57%（p = 0.005）。在考克斯多变量分析中，Child组和≤ 50 ms的最小TpTe是复合终点的独立预测因素。QT间期、QTc间期、DQT间期、DQTc间期和TpTe间期在阿尔茨海默病不同严重程度阶段之间具有相似的分布。TpTe间期被证明是肝硬化受试者的预后标志物，无论疾病严重程度如何（NCT 01433848）。
There is still debate about the relationship between changes in ventricular repolarization on the surface electrocardiogram and cirrhosis severity. To study the relationship between variables related to ventricular repolarization and the clinical severity of the cirrhotic disease. We selected 79 individuals with hepatic cirrhosis, classified according to the Child-Pugh-Turcotte criteria (Child A, B, and C). We measured the QT and corrected QT (QTc) intervals, and the interval between the peak and the end of the T wave (TpTe), and we identified their minimum, maximum, and mean values in the 12-lead electrocardiogram. We also calculated the dispersion of the QT (DQT) and QTc (DQTc) intervals. In 12 months of clinical follow-up, nine subjects underwent hepatic transplantation (Child A: 0 [0%]; Child B: 6 [23.1%]; Child C: 3 [18.8%]; p = 0.04) and 12 died (Child A: 3 [12.0%]; Child B: 4 [15.4%]; Child C: 5 [31.3%]; p = 0.002). No significant differences were observed between the cirrhotic groups related to the minimum, maximum, and mean values for the QT, QTc, TpTe, DQT, and DQTc intervals. A minimum TpTe interval ≤ 50 ms was a predictor for the composite endpoints of death or liver transplantation with a sensitivity of 90% and a specificity of 57% (p = 0.005). In the Cox multivariate analysis, the Child groups and a minimum TpTe of ≤ 50 ms were independent predictors of the composite endpoints. The intervals QT, QTc, DQT, DQTc, and TpTe have similar distributions between different severity stages in cirrhotic disease. The TpTe interval proved to be a prognostic marker in subjects with cirrhosis, regardless of disease severity (NCT01433848).
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影响因子：
1.3
作者：
Rautaharju, Pentti M.;Zhang, Zhu-ming;Gregg, Richard E.;Haisty, Wesley K., Jr.;Vitolins, Mara Z.;Curtis, Anne B.;Warren, James;Horacek, Milan B.;Zhou, Sophia H.;Soliman, Elsayed Z.
通讯作者：
Soliman, Elsayed Z.
影响因子：
168.9
作者：
HENDRICKSE, MT;THULUVATH, PJ;TRIGER, DR
通讯作者：
TRIGER, DR
影响因子：
0.9
作者：
Timoh, T.;Protano, M. A.;Vittorio, T. J.
通讯作者：
Vittorio, T. J.
影响因子：
3.9
作者：
Bernardi, Mauro;Maggioli, Caterina;Zaccherini, Giacomo
通讯作者：
Zaccherini, Giacomo
影响因子：
1.3
作者：
Gupta, Prasad;Patel, Chinmay;Yan, Gan-Xin
通讯作者：
Yan, Gan-Xin