Normal standards for computer-ECG programs for prognostically and diagnostically important ECG variables derived from a large ethnically diverse female cohort: the Women's Health Initiative (WHI).
Normal standards for computer-ECG programs for prognostically and diagnostically important ECG variables derived from a large ethnically diverse female cohort: the Women's Health Initiative (WHI).
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DOI：
10.1016/j.jelectrocard.2013.05.136
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发表时间：
2013-11
影响因子：
1.3
通讯作者：
Soliman, Elsayed Z.
中科院分区：
文献类型：
--
作者：
Rautaharju, Pentti M.;Zhang, Zhu-ming;Gregg, Richard E.;Haisty, Wesley K., Jr.;Vitolins, Mara Z.;Curtis, Anne B.;Warren, James;Horacek, Milan B.;Zhou, Sophia H.;Soliman, Elsayed Z.
最近出现了关于各种新心电图变量的预后价值的大量新信息。本研究的目的是为来自妇女健康倡议 (WHI) 研究的大量、不同种族的健康女性群体中的这些新型风险预测因素建立参考标准。研究对象包括 36,299 名健康的不同种族女性。作为 RR 线性函数的速率调整 QT 结束 (QTea) 和 QT 峰值 (QTpa) 间隔的种族差异很小，得出的结论是，450 ms 和 390 ms 适用于延长和缩短 QTea 的阈值，类似地，延长和缩短 QTpa 的阈值分别为 365 ms 和 295。作为全球复极离散度增加的阈值（TpeakTend 间隔），白人和西班牙裔女性设定为 110 毫秒，非裔美国和亚洲女性设定为 120 毫秒。使用根据 116 个导联体表电位图计算的导联转换矩阵导出正常标准，以导出使用 Mason-Likar 位置的肢体电极和 V1-V2 水平的胸导联 V3-V6 以及双极血管特异性左前降支 (LAD)、左回旋支 (LCX) 和右冠状动脉 (RCA) 导联进行 ST 监测的正常标准。结果支持选择 150 μV 作为所有监测导联异常 ST 起始抬高的暂定阈值。体重指数 (BMI) 对所有种族群体的康奈尔电压和索科洛-里昂电压都有深远的影响，其对左心室肥厚分类的效用仍然存在。所有种族群体的通用阈值均适用于 QTea、QTpa 间期和 ST 抬高。许多其他心电图参数需要特定于比赛的正常标准。
Substantial new information has emerged recently about the prognostic value for a variety of new ECG variables. The objective of the present study was to establish reference standards for these novel risk predictors in a large, ethnically diverse cohort of healthy women from the Women's Health Initiative (WHI) study. The study population consisted of 36,299 healthy racially diverse women. Racial differences in rate-adjusted QT end (QTea) and QT peak (QTpa) intervals as linear functions of RR were small, leading to the conclusion that 450 ms and 390 ms are applicable as thresholds for prolonged and shortened QTea and similarly, 365 ms and 295 for prolonged and shortened QTpa, respectively. As a threshold for increased dispersion of global repolarization (TpeakTend interval), 110 ms was established for white and Hispanic women and 120 ms for African-American and Asian women. Normal standards were derived using lead transformation matrix computed from 116 lead body surface potential maps to derive normal standards for ST monitoring with limb electrodes in Mason-Likar positions and chest leads V3-V6 at the level of V1-V2 and for bipolar vessel-specific left anterior descending (LAD), left circumflex (LCX) and right coronary artery (RCA) leads. The results support the choice 150 μV as a tentative threshold for abnormal ST onset elevation for all monitoring leads. Body mass index (BMI) had a profound effect on Cornell voltage and Sokolow-Lyon voltage in all racial groups and their utility for left ventricular hypertrophy classification remains open. Common thresholds for all racial groups are applicable for QTea, and QTpa intervals and ST elevation. Race-specific normal standards are required for many other ECG parameters.
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影响因子：
1.3
作者：
Horácek, BM;Warren, JW;Feldman, CL
通讯作者：
Feldman, CL
影响因子：
2.8
作者：
Lown, Mark T.;Munyombwe, Theresa;Gale, Chris P.
通讯作者：
Gale, Chris P.
影响因子：
1.3
作者：
Gupta, Prasad;Patel, Chinmay;Yan, Gan-Xin
通讯作者：
Yan, Gan-Xin
影响因子：
37.8
作者：
Kurl, Sudhir;Makikallio, Timo H.;Laukkanen, Jari A.
通讯作者：
Laukkanen, Jari A.
影响因子：
1.3
作者：
Andersen, Mads P.;Xue, Joel Q.;Struijk, Johannes J.
通讯作者：
Struijk, Johannes J.