Cell membrane water exchange effects in prostate DCE-MRI.
Cell membrane water exchange effects in prostate DCE-MRI.
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DOI：
10.1016/j.jmr.2012.03.019
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发表时间：
2012-05
影响因子：
2.2
通讯作者：
Springer, Charles S., Jr.
中科院分区：
文献类型：
--
作者：
Li, Xin;Priest, Ryan A.;Woodward, William J.;Siddiqui, Faisal;Beer, Tomasz M.;Garzotto, Mark G.;Rooney, William D.;Springer, Charles S., Jr.
前列腺动态对比增强（DCE） MRI经常显示快速和广泛的整体造影剂（CR）外渗-通过Ktrans测量，一个药代动力学参数与其速率成正比。这意味着在大部分DCE-MRI研究中，细胞外、血管外空间（EES）的CR浓度（[CR]）很高。由于[CR]是通过水质子信号的改变间接检测到的，因此在数据中，平衡的经细胞乳水交换的影响可能是显著的，因此在DCE-MRI药代动力学建模中应该考虑。通过模拟和分析不同模型的实际前列腺数据，探讨了参数值的含义。并对模型参数的相关性和精度进行了探讨。找到了一个近乎最优的交换敏感模型。我们的结果表明ΔKtrans（该版本和假设交换有效无限快的模型返回的Ktrans差异）可能是区分前列腺组织恶性和良性的非常有用的生物标志物。使用交换敏感模型，我们发现平均细胞内水寿命(τi) -一种交换措施-可以有意义地映射前列腺。我们的结果显示前列腺区τi值的差异。
Prostate Dynamic-Contrast-Enhanced (DCE) MRI often exhibits fast and extensive global contrast reagent (CR) extravasation - measured by Ktrans, a pharmacokinetic parameter proportional to its rate. This implies that the CR concentration ([CR]) is high in the extracellular, extravascular space (EES) during a large portion of the DCE-MRI study. Since [CR] is detected indirectly, through water proton signal change, the effects of equilibrium transcytolemmal water exchange may be significant in the data and thus should be admitted in DCE-MRI pharmacokinetic modeling. The implications for parameter values were investigated through simulations, and analyses of actual prostate data, with different models. Model parameter correlation and precision were also explored. A near-optimal version of the exchange-sensitized model was found. Our results indicate that ΔKtrans (the Ktrans difference returned by this version and a model assuming exchange to be effectively infinitely fast) may be a very useful biomarker for discriminating malignant from benign prostate tissue. Using an exchange-sensitized model, we find that the mean intracellular water lifetime (τi) - an exchange measure - can be meaningfully mapped for the prostate. Our results show prostate glandular zone differences in τi values.
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DOI：
10.1073/pnas.0804224105
发表时间：
2008-11-18
影响因子：
11.1
作者：
Li, Xin;Huang, Wei;Springer, Charles S., Jr.
通讯作者：
Springer, Charles S., Jr.
DOI：
10.4261/1305-3825.dir.2537-08.1
发表时间：
2010-09
期刊：
Diagnostic and interventional radiology (Ankara, Turkey)
影响因子：
--
作者：
Türkbey B;Thomasson D;Pang Y;Bernardo M;Choyke PL
通讯作者：
Choyke PL
影响因子：
3.3
作者：
Alonzi, Roberto;Padhani, Anwar R.;Allen, Clare
通讯作者：
Allen, Clare
影响因子：
3.3
作者：
Buckley, David L.;Kershaw, Lucy E.;Stanisz, Greg J.
通讯作者：
Stanisz, Greg J.
影响因子：
19.7
作者：
Oto, Aytekin;Kayhan, Arda;Stadler, Walter M.
通讯作者：
Stadler, Walter M.