The UDP-Glycosyltransferase Family in Drosophila melanogaster: Nomenclature Update, Gene Expression and Phylogenetic Analysis.
The UDP-Glycosyltransferase Family in Drosophila melanogaster: Nomenclature Update, Gene Expression and Phylogenetic Analysis.
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DOI：
10.3389/fphys.2021.648481
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发表时间：
2021
影响因子：
4
通讯作者：
Marygold SJ
中科院分区：
文献类型：
--
作者：
Ahn SJ;Marygold SJ
UDP-糖基转移酶（UGT）是在所有生命王国中发现的重要的缀合酶，催化糖与小的亲脂性化合物的缀合，并在解毒和体内平衡中起关键作用。UGT基因家族由尿苷二磷酸（UDP）-糖供体结合的C-末端结构域中的特征基序定义。在过去的十年中，UGT在许多昆虫基因组中被鉴定，并且在表征其表达模式和分子功能方面取得了很大进展。在这里，我们提出了一个更新的完整剧目的UGT基因在果蝇，并提供了一个简短的概述，在这个模式昆虫的最新研究。在D.黑腹果蝇基因组，定位于染色体2和3与染色体臂3R上的基因高度重复。全是D。根据统一的UGT命名指南，黑腹果蝇UGT基因现已在FlyBase中命名。UGT基因的系统发育分析显示谱系特异性基因重复。解剖学和诱导基因表达模式的分析表明，一些UGT基因在各种组织中或环境处理后差异表达。对另外18个果蝇物种的UGT直系同源物的扩展搜索揭示了UGT基因数量和组成的多样性。本文简要综述了果蝇UGT的作用，包括外源性物质代谢、尼古丁抗性、嗅觉、耐寒性、硬化、色素沉着和免疫。总之，本文提供的最新基因组信息和研究概述将有助于这一发展中领域的进一步研究。
UDP-glycosyltransferases (UGTs) are important conjugation enzymes found in all kingdoms of life, catalyzing a sugar conjugation with small lipophilic compounds and playing a crucial role in detoxification and homeostasis. The UGT gene family is defined by a signature motif in the C-terminal domain where the uridine diphosphate (UDP)-sugar donor binds. UGTs have been identified in a number of insect genomes over the last decade and much progress has been achieved in characterizing their expression patterns and molecular functions. Here, we present an update of the complete repertoire of UGT genes in Drosophila melanogaster and provide a brief overview of the latest research in this model insect. A total of 35 UGT genes are found in the D. melanogaster genome, localized to chromosomes 2 and 3 with a high degree of gene duplications on the chromosome arm 3R. All D. melanogaster UGT genes have now been named in FlyBase according to the unified UGT nomenclature guidelines. A phylogenetic analysis of UGT genes shows lineage-specific gene duplications. Analysis of anatomical and induced gene expression patterns demonstrate that some UGT genes are differentially expressed in various tissues or after environmental treatments. Extended searches of UGT orthologs from 18 additional Drosophila species reveal a diversity of UGT gene numbers and composition. The roles of Drosophila UGTs identified to date are briefly reviewed, and include xenobiotic metabolism, nicotine resistance, olfaction, cold tolerance, sclerotization, pigmentation, and immunity. Together, the updated genomic information and research overview provided herein will aid further research in this developing field.
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影响因子：
4
作者：
Israni B;Wouters FC;Luck K;Seibel E;Ahn SJ;Paetz C;Reinert M;Vogel H;Erb M;Heckel DG;Gershenzon J;Vassão DG
通讯作者：
Vassão DG
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3.3
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Highfill CA;Tran JH;Nguyen SKT;Moldenhauer TR;Wang X;Macdonald SJ
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影响因子：
14.9
作者：
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通讯作者：
Zdobnov EM
影响因子：
14.9
作者：
Leader DP;Krause SA;Pandit A;Davies SA;Dow JAT
通讯作者：
Dow JAT
影响因子：
5.8
作者：
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通讯作者：
Bock, Karl Walter