Person-to-person transmission of Nipah virus in a Bangladeshi community.
Person-to-person transmission of Nipah virus in a Bangladeshi community.
复制标题
DOI：
10.3201/eid1307.061128
复制
发表时间：
2007-07
影响因子：
11.8
通讯作者：
Breiman RF
中科院分区：
文献类型：
--
作者：
Gurley ES;Montgomery JM;Hossain MJ;Bell M;Azad AK;Islam MR;Molla MA;Carroll DS;Ksiazek TG;Rota PA;Lowe L;Comer JA;Rollin P;Czub M;Grolla A;Feldmann H;Luby SP;Woodward JL;Breiman RF
这种病毒的传播突出表明，需要在资源贫乏的环境中制定感染控制战略。2004年4 - 5月，对孟加拉国法里德布尔区的一起脑炎暴发进行了调查，以确定暴发的原因和疾病的危险因素。对生物标本进行尼帕病毒检测。通过使用逆转录-PCR（RT-PCR）评估表面的尼帕病毒污染。确定了36例尼帕病毒病; 75%的病例患者死亡。出现多个发病高峰，33名病例患者在发病前与另一名尼帕病毒患者有密切接触。一项病例对照研究的结果显示，与1名患者接触具有最高的感染风险（比值比6.7，95%置信区间2.9-16.8，p<0.001）。对环境样本的RT-PCR检测证实医院表面受到尼帕病毒污染。这项调查为尼帕病毒的人际传播提供了证据。人与人之间的传播能力增加了这种高度致命病原体更广泛传播的可能性，并突出表明需要在资源贫乏的环境中制定感染控制战略。
Transmission of this virus highlights the need for infection control strategies for resource-poor settings. An encephalitis outbreak was investigated in Faridpur District, Bangladesh, in April–May 2004 to determine the cause of the outbreak and risk factors for disease. Biologic specimens were tested for Nipah virus. Surfaces were evaluated for Nipah virus contamination by using reverse transcription–PCR (RT-PCR). Thirty-six cases of Nipah virus illness were identified; 75% of case-patients died. Multiple peaks of illness occurred, and 33 case-patients had close contact with another Nipah virus patient before their illness. Results from a case-control study showed that contact with 1 patient carried the highest risk for infection (odds ratio 6.7, 95% confidence interval 2.9–16.8, p<0.001). RT-PCR testing of environmental samples confirmed Nipah virus contamination of hospital surfaces. This investigation provides evidence for person-to-person transmission of Nipah virus. Capacity for person-to-person transmission increases the potential for wider spread of this highly lethal pathogen and highlights the need for infection control strategies for resource-poor settings.
登录
查看更多内容
影响因子：
11.8
作者：
Olson, JG;Rupprecht, C;Ksiazek, TG
通讯作者：
Ksiazek, TG
影响因子：
6.4
作者：
Chew, MHL;Arguin, PM;Anderson, LJ
通讯作者：
Anderson, LJ
影响因子：
11.8
作者：
Lam, SK;Chua, KB
通讯作者：
Chua, KB
影响因子：
2.9
作者：
CHOMCZYNSKI, P;SACCHI, N
通讯作者：
SACCHI, N
影响因子：
3.7
作者：
Harcourt, BH;Tamin, A;Rota, PA
通讯作者：
Rota, PA