Modeling human neurodevelopmental disorders in the Xenopus tadpole: from mechanisms to therapeutic targets.
Modeling human neurodevelopmental disorders in the Xenopus tadpole: from mechanisms to therapeutic targets.
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DOI：
10.1242/dmm.012138
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发表时间：
2013-09
影响因子：
4.3
通讯作者：
Khakhalin AS
中科院分区：
文献类型：
--
作者：
Pratt KG;Khakhalin AS
非洲爪蟾蝌蚪模型为研究神经发育障碍的分子、细胞和网络机制提供了许多优势。基本上，正常神经回路发育的每一个阶段，从轴突生长和指导到活动依赖的稳态和完善，都已经在青蛙蝌蚪中进行了研究，这使得它成为一个理想的模型，以确定当这些阶段中的任何一个受到损害时会发生什么。最近，蝌蚪模型已被用于探索癫痫和自闭症的机制，越来越多的证据表明，神经系统疾病涉及神经系统功能和发育的最基本方面的缺陷。在这篇综述中，我们提供了关于如何使用蝌蚪模型研究三种不同类型的神经发育障碍的最新信息：暴露于环境毒物引起的疾病，癫痫和癫痫发作障碍以及自闭症。
The Xenopus tadpole model offers many advantages for studying the molecular, cellular and network mechanisms underlying neurodevelopmental disorders. Essentially every stage of normal neural circuit development, from axon outgrowth and guidance to activity-dependent homeostasis and refinement, has been studied in the frog tadpole, making it an ideal model to determine what happens when any of these stages are compromised. Recently, the tadpole model has been used to explore the mechanisms of epilepsy and autism, and there is mounting evidence to suggest that diseases of the nervous system involve deficits in the most fundamental aspects of nervous system function and development. In this Review, we provide an update on how tadpole models are being used to study three distinct types of neurodevelopmental disorders: diseases caused by exposure to environmental toxicants, epilepsy and seizure disorders, and autism.
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影响因子：
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作者：
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通讯作者：
Cline, Hollis T.
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影响因子：
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作者：
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通讯作者：
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